Plasmodium falciparum accompanied the human expansion out of Africa

Tanabe, K. et al. (2010) Plasmodium falciparum accompanied the human expansion out of Africa. Current Biology, 20(14), pp. 1283-1289. (doi:10.1016/j.cub.2010.05.053)

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Abstract

Plasmodium falciparum is distributed throughout the tropics and is responsible for an estimated 230 million cases of malaria every year, with a further 1.4 billion people at risk of infection [1-3]. Little is known about the genetic makeup of P. falciparum populations, despite variation in genetic diversity being a key factor in morbidity, mortality, and the success of malaria control initiatives. Here we analyze a worldwide sample of 519 P. falciparum isolates sequenced for two housekeeping genes (63 single nucleotide polymorphisms from around 5000 nucleotides per isolate). We observe a strong negative correlation between within-population genetic diversity and geographic distance from sub-Saharan Africa (R2 = 0.95) over Africa, Asia, and Oceania. In contrast, regional variation in transmission intensity seems to have had a negligible impact on the distribution of genetic diversity. The striking geographic patterns of isolation by distance observed in P. falciparum mirror the ones previously documented in humans [4-7] and point to a joint sub-Saharan African origin between the parasite and its host. Age estimates for the expansion of P. falciparum further support that anatomically modern humans were infected prior to their exit out of Africa and carried the parasite along during their colonization of the world.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Ranford-Cartwright, Dr Lisa
Authors: Tanabe, K., Mita, T., Jombart, T., Eriksson, A., Horibe, S., Palacpac, N., Ranford-Cartwright, L.C., Sawai, H., Sakihama, N., Ohmae, H., Nakamura, M., Ferreira, M.U., Escalante, A.A., Prugnolle, F., Björkman, A., Färnert, A., Kaneko, A., Horii, T., Manica, A., Kishino, H., and Balloux, F.
Subjects:Q Science > QH Natural history > QH301 Biology
College/School:College of Medical Veterinary and Life Sciences > Institute of Infection Immunity and Inflammation
Journal Name:Current Biology
Publisher:Elsevier
ISSN:0960-9822
ISSN (Online):1879-0445
Published Online:17 June 2010
Copyright Holders:Copyright © 2010 Elsevier
First Published:First published in Current Biology 20(14):1283-1289
Publisher Policy:Reproduced in accordance with the copyright policy of the publisher

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