Targeting telomerase: therapeutic options for cancer treatment

Keith, W.N. and Bilsland, A.E. (2008) Targeting telomerase: therapeutic options for cancer treatment. In: Rudolph, K.L. (ed.) Telomeres and Telomerase in Aging, Disease, and Cancer: Molecular Mechanisms of Adult Stem Cell Ageing. Springer: Berlin, Germany, pp. 247-283. ISBN 9783540737087 (doi:10.1007/978-3-540-73709-4_13)

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Abstract

Telomerase is a suitable target for drug development because of its high prevalence, selective expression, and mechanistic importance in many cancer types. Telomerase targeting strategies can be defi ned as immunotherapy, gene therapy, and inhibition either by oligonucleotides or small molecules. However, few published approaches have entered clinical testing. There are advantages and limitations to each approach, and their different mechanisms of action must be taken into account in order to design appropriate preclinical models and identify appropriate endpoints for clinical trials. In this chapter we review the development pipelines for each class of telomerase-directed therapeutics, summarizing future challenges, opportunities, and development gaps.

Item Type:Book Sections
Keywords:Adult, cancer, disease, mechanisms, stem cell, targeting, telomerase, telomere, treatment
Status:Published
Glasgow Author(s) Enlighten ID:Bilsland, Dr Alan and Keith, Professor Nicol
Authors: Keith, W.N., and Bilsland, A.E.
Subjects:R Medicine > RC Internal medicine > RC0254 Neoplasms. Tumors. Oncology (including Cancer)
College/School:College of Medical Veterinary and Life Sciences > Institute of Cancer Sciences
Publisher:Springer
ISBN:9783540737087

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