3D mapping of microfluidic flow in laboratory-on-a-chip structures using optical tweezers

Mushfique, H., Leach, J., Yin, H. , Di Leonardo, R., Padgett, M.J. and Cooper, J.M. (2008) 3D mapping of microfluidic flow in laboratory-on-a-chip structures using optical tweezers. Analytical Chemistry, 80(11), pp. 4237-4240. (doi:10.1021/ac8002006)

Mushfique, H., Leach, J., Yin, H. , Di Leonardo, R., Padgett, M.J. and Cooper, J.M. (2008) 3D mapping of microfluidic flow in laboratory-on-a-chip structures using optical tweezers. Analytical Chemistry, 80(11), pp. 4237-4240. (doi:10.1021/ac8002006)

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Publisher's URL: http://dx.doi.org/10.1021/ac8002006

Abstract

Accurate measurement of flow in microfluidic systems is both challenging and important, providing information that can be used to better understand flow fields within laboratory-on-a-chip devices and validate computational simulations. Here, we use optical tweezers within a microfluidic system to measure the velocity vectors of flow fields in two and three dimensions around a microstructures including both molded features within channels and cells. The experimental results are compared to a complex fluid dynamics model showing an agreement between the two of better than 3 mu m/s. This measurement is highly reproducible and minimally invasive, which in the future could be used to provided more in-depth studies of the rheological properties of biological cells and microstructures in laboratory-on-a-chip devices.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Yin, Professor Huabing and Padgett, Professor Miles and Cooper, Professor Jonathan and Leach, Mr Jonathan
Authors: Mushfique, H., Leach, J., Yin, H., Di Leonardo, R., Padgett, M.J., and Cooper, J.M.
College/School:College of Science and Engineering > School of Physics and Astronomy
College of Science and Engineering > School of Engineering > Biomedical Engineering
Journal Name:Analytical Chemistry
ISSN:0003-2700

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