Hart, C.L., Davey Smith, G., Hole, D.J., and Hawthorne, V.M. (1999) Alcohol consumption and mortality from all causes, coronary heart disease, and stroke: results from a prospective cohort study of Scottish men with 21 years of follow up. British Medical Journal, 318(7200), pp. 1725-1729.
Objectives: To relate alcohol consumption to mortality. Design: Prospective cohort study. Setting: 27 workplaces in the west of Scotland. Participants: 5766 men aged 35-64 when screened in 1970-3 who answered questions on their usual weekly alcohol consumption. Main outcome measures: Mortality from all causes, coronary heart disease, stroke, and alcohol related causes over 21 years of follow up related to units of alcohol consumed per week. Results: Risk for all cause mortality was similar for non-drinkers and men drinking up to 14 units a week. Mortality risk then showed a graded association with alcohol consumption (relative rate compared with non-drinkers 1.34 (95% confidence interval 1.14 to 1.58) for 15-21 units a week, 1.49 (1.27 to 1.75) for 22-34 units, 1.74 (1.47 to 2.06) for 35 or more units). Adjustment for risk factors attenuated the increased relative risks, but they remained significantly above 1 for men drinking 22 or more units a week. There was no strong relation between alcohol consumption and mortality from coronary heart disease after adjustment. A strong positive relation was seen between alcohol consumption and risk of mortality from stroke, with men drinking 35 or more units having double the risk of non-drinkers, even after adjustment. Conclusions: The overall association between alcohol consumption and mortality is unfavourable for men drinking over 22 units a week, and there is no clear evidence of any protective effect for men drinking less than this.
|Glasgow Author(s) Enlighten ID:||Hart, Dr Carole and Davey Smith, Professor George and Hole, Prof David|
|Authors:||Hart, C.L., Davey Smith, G., Hole, D.J., and Hawthorne, V.M.|
|Subjects:||R Medicine > RA Public aspects of medicine|
|College/School:||College of Medical Veterinary and Life Sciences|
|Journal Name:||British Medical Journal|
|Publisher:||BMJ Publishing Group|
|Copyright Holders:||Copyright © 1999 BMJ Publishing Group|
|First Published:||First published in British Medical Journal 318(7200):1725-1729|
|Publisher Policy:||Reproduced in accordance with the copyright policy of the publisher|