The natural history of chronic obstructive pulmonary disease

Mannino, D.M. et al. (2006) The natural history of chronic obstructive pulmonary disease. European Respiratory Journal, 27(3), pp. 627-643. (doi: 10.1183/​09031936.06.00024605)

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Abstract

Chronic obstructive pulmonary disease (COPD) is a leading cause of morbidity and mortality in the USA, and it remains one of the few diseases that continues to increase its numbers. The development and progression of COPD can vary dramatically between individuals. A low level of lung function remains the cornerstone of COPD diagnosis and is a key predictor of prognosis. Lung function, however, is not the only factor in determining morbidity and mortality related to COPD, with factors such as body mass index, exercise capability and comorbid disease being important predictors of poor outcomes. Exacerbations of COPD are additional important indicators of both quality of life and outcomes in COPD patients. Definitions of exacerbations can vary, ranging from an increase in symptoms to COPD-related hospitalisations and death. COPD exacerbations are more common in patients with lower levels of lung function and may lead to more rapid declines in lung function. Better understanding of the natural history of COPD may lead to better definitions of specific COPD phenotypes, better interventions and improved outcomes.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:McConnachie, Professor Alex and Hart, Dr Carole and Gillis, Prof Charles and Davey Smith, Professor George and Hole, Prof David and Watt, Professor Graham
Authors: Mannino, D.M., Watt, G., Hole, D., Gillis, C., Hart, C., McConnachie, A., Davey Smith, G., Upton, M., Hawthorne, V., Sin, D.D., Man, S.F.P., Van Eden, S., Mapel, D.W., and Vestbo, J.
Subjects:R Medicine > RA Public aspects of medicine
R Medicine > RC Internal medicine
College/School:College of Medical Veterinary and Life Sciences > Institute of Health and Wellbeing > Robertson Centre
College of Medical Veterinary and Life Sciences > Institute of Health and Wellbeing > Public Health
College of Medical Veterinary and Life Sciences > Institute of Health and Wellbeing > General Practice and Primary Care
College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing > Centre for Population and Health Sciences
Research Group:Midspan
Journal Name:European Respiratory Journal
Publisher:European Respiratory Society
ISSN:0903-1936
ISSN (Online):1399-3003
Copyright Holders:Copyright © 2006 European Respiratory Society
First Published:First published in European Respiratory Journal 27(3):627-643
Publisher Policy:Reproduced in accordance with the copyright policy of the publisher

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