Use of CD134 as a primary receptor by the feline immunodeficiency virus

Shimojima, M., Miyazawa, T., Ikeda, Y., McMonagle, E.L., Haining, H., Akashi, H., Takeuchi, Y., Hosie, M.J. and Willett, B.J. (2004) Use of CD134 as a primary receptor by the feline immunodeficiency virus. Science, 303(20), pp. 1192-1195. (doi: 10.1126/science.1092124)

Abstract

Feline immunodeficiency virus (FIV) induces a disease similar to acquired immunodeficiency syndrome (AIDS) in cats, yet in contrast to human immunodeficiency virus (HIV), CD4 is not the viral receptor. We identified a primary receptor for FIV as CD134 (OX40), a T cell activation antigen and costimulatory molecule. CD134 expression promotes viral binding and renders cells permissive for viral entry, productive infection, and syncytium formation. Infection is CXCR4-dependent, analogous to infection with X4 strains of HIV. Thus, despite the evolutionary divergence of the feline and human lentiviruses, both viruses use receptors that target the virus to a subset of cells that are pivotal to the acquired immune response.

• Item Type: Articles
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Hosie, Professor Margaret and Willett, Professor Brian and Haining, Dr Hayley and McMonagle, Mrs Linda
• Authors: Shimojima, M., Miyazawa, T., Ikeda, Y., McMonagle, E.L., Haining, H., Akashi, H., Takeuchi, Y., Hosie, M.J., and Willett, B.J.
• Subjects: S Agriculture > SF Animal culture > SF600 Veterinary Medicine; Q Science > QR Microbiology > QR355 Virology
• College/School: College of Medical Veterinary and Life Sciences > School of Veterinary Medicine; College of Medical Veterinary and Life Sciences > Institute of Infection Immunity and Inflammation
• Journal Name: Science
• Publisher: American Association for the Advancement of Science
• ISSN: 0036-8075
• ISSN (Online): 1095-9203
• Copyright Holders: Copyright © 2004 American Association for the Advancement of Science
• First Published: First published in Science 303(20):1192-1195
• Publisher Policy: Reproduced in accordance with the copyright policy of the publisher