The E5 oncoprotein of BPV-4 does not interfere with the biosynthetic pathway of non-classical MHC class I

Araibi, E.H., Marchetti, B., Dornan, E.S., Ashrafi, G.H., Dobromylskyj, D., Ellis, S.A. and Campo, M.S. (2006) The E5 oncoprotein of BPV-4 does not interfere with the biosynthetic pathway of non-classical MHC class I. Virology, 353(1), pp. 174-183. (doi:10.1016/j.virol.2006.05.031)

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Publisher's URL: http://dx.doi.org/10.1016/j.virol.2006.05.031

Abstract

The major histocompatibility complex (MHC) class I region in mammals contains both classical and non-classical MHC class I genes. Classical MHC class I molecules present antigenic peptides to cytotoxic T lymphocytes, whereas non-classical MHC class I molecules have a variety of functions. Both classical and non-classical MHC molecules interact with natural killer cell receptors and may under some circumstances prevent cell death by natural killer cytotoxicity. The E5 oncoprotein of BPV-4 down-regulates the expression of classical MHC class I on the cell surface and retains the complex in the Golgi apparatus. The inhibition of classical MHC class I to the cell surface results from both the impaired acidification of the Golgi, due to the interaction of E5 with subunit c of the H+ V-ATPase, and to the physical binding of E5 to the heavy chain of MHC class I. Despite the profound effect of E5 on classical MHC class I, E5 does not retain a non-classical MHC class I in the Golgi, does not inhibit its transport to the cell surface and does not bind its heavy chain. We conclude that, as is the case for HPV-16 E5, BPV-4 E5 does not down-regulate certain non-classical MHC class I, potentially providing a mechanism for the escape of the infected cell from attack by both cytotoxic T lymphocytes and NK cells.

Item Type:Articles
Keywords:BPV; E5; Classical MHC class I; Non-classical MHC class I; E5-MHC class I interaction; MHC class I down-regulation
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Ashrafi, Dr Gholam Hossein and Campo, Professor Saveria and Marchetti, Dr Barbara and Dornan, Mr Edward
Authors: Araibi, E.H., Marchetti, B., Dornan, E.S., Ashrafi, G.H., Dobromylskyj, D., Ellis, S.A., and Campo, M.S.
Subjects:Q Science > QR Microbiology > QR180 Immunology
S Agriculture > SF Animal culture > SF600 Veterinary Medicine
College/School:College of Medical Veterinary and Life Sciences
Journal Name:Virology
Publisher:Elsevier Science
ISSN:1096-0341
Copyright Holders:Copyright © 2006 Elsevier Science
First Published:First published in Virology 353(1):174-183
Publisher Policy:Reproduced in accordance with the copyright policy of the publisher

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