The third-stage larva (L3) of Brugia: its role in immune modulation and protective immunity.

Devaney, E. and Osborne, J. (2000) The third-stage larva (L3) of Brugia: its role in immune modulation and protective immunity. Microbes and Infection, 2(11), pp. 1363-71. (doi:10.1016/S1286-4579(00)01290-9) (PMID:11018453)

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Abstract

In this review, we focus on the role of the L3 (third-stage larva) of lymphatic filarial nematodes in immunomodulation and in the development of protective immunity. Studies in the mouse models of Brugia have been fundamental to our understanding of the mechanisms by which infection with L3 results in Th2 responses and the active suppression of Th1 responses. The relevance of these phenomena to the human infection is discussed.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Devaney, Professor Eileen
Authors: Devaney, E., and Osborne, J.
College/School:College of Medical Veterinary and Life Sciences > Institute of Biodiversity Animal Health and Comparative Medicine
Journal Name:Microbes and Infection
Publisher:Elsevier
ISSN:1286-4579
ISSN (Online):1769-714X
Published Online:28 September 2000

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