Trilostane in dogs

Ramsey, I.K. (2010) Trilostane in dogs. Veterinary Clinics of North America: Small Animal Practice, 40(2), pp. 269-283. (doi: 10.1016/j.cvsm.2009.10.008)

Abstract

Over the last 10 years, trilostane, a competitive inhibitor of steroid synthesis, is being widely used for the treatment of canine hyperadrenocorticism. Trilostane causes a significant but reversible decrease in cortisol production and a concomitant improvement in clinical signs in most dogs with this common condition. Side effects, though infrequent, can be serious: dogs treated with this drug require regular monitoring. This review summarizes current knowledge of the use of this drug with particular emphasis on its efficacy, safety, adverse reactions, and effects on endocrine parameters. Brief mention is made of its other uses in dogs and other species.

• Item Type: Articles
• Keywords: Hyperadrenocorticism, treatment, adrenal, steroid synthesis inhibitor
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Ramsey, Professor Ian
• Authors: Ramsey, I.K.
• Subjects: S Agriculture > SF Animal culture > SF600 Veterinary Medicine
• College/School: College of Medical Veterinary and Life Sciences > School of Biodiversity, One Health & Veterinary Medicine
• Journal Name: Veterinary Clinics of North America: Small Animal Practice
• Publisher: Elsevier
• ISSN: 0195-5616
• ISSN (Online): 1878-1306
• Published Online: 26 February 2010
• Copyright Holders: Copyright © 2010 Elsevier
• First Published: First published in Veterinary Clinics of North America: Small Animal Practice 40(2):269-283
• Publisher Policy: Reproduced in accordance with the copyright policy of the publisher