Monitoring the response of canine hyperadrenocorticism to trilostane treatment by assessment of acute phase protein concentrations

Arteaga, A., Dhand, N.K., McCann, T., Knottenbelt, C.M., Tebb, A.J., Evans, H., Eckersall, P.D. and Ramsey, I.K. (2010) Monitoring the response of canine hyperadrenocorticism to trilostane treatment by assessment of acute phase protein concentrations. Journal of Small Animal Practice, 51(4), pp. 204-209. (doi:10.1111/j.1748-5827.2009.00863.x)

[img] Text
30474.pdf

274kB

Abstract

<b>Background</b>: Acute phase proteins (APPS) include haptoglobin (Hp), C-reactive protein (CRP) and serum amyloid A (SAA). Increased Hp concentrations may be induced by endogenous or exogenous glucocorticoids in dogs. <b>Objectives</b>: To assess whether control of hyperadrenocorticism (HAC) affects the concentrations of Hp, CRP, SAA, alkaline phosphatase (ALKP) and cholesterol, to determine whether these analytes can be used to assess control of HAC following trilostane treatment, and whether a combination of these tests offers a valid method of assessing disease control. <b>Methods</b>: Hp, CRP, SAA, ALKP and cholesterol were assessed in 11 dogs with spontaneous HAC before and after treatment with trilostane. Adequate control of HAC was defined as post-ACTH cortisol less than 150 nmol/l. <b>Results</b>: Significant reductions in Hp, ALKP, cholesterol and SAA (P<0·05) but not of CRP were found after control of HAC. Only Hp, cholesterol and ALKP were moderately informative (Se & Sp>0·7) of disease control when compared to adrenocorticotropin or corticotropin (ACTH) stimulation test. SAA and CRP were unhelpful (Se & Sp<0·7). The analysis of the combination of the analytes did not improve the correlation with ACTH stimulation test. <b>Clinical Relevance</b>: Relying on these analytes does not provide additional information over ACTH stimulation test results when assessing control of HAC treated with trilostane.

Item Type:Articles
Additional Information:The definitive version is available at www3.interscience.wiley.com
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Eckersall, Professor David and Ramsey, Professor Ian and Knottenbelt, Professor Clare
Authors: Arteaga, A., Dhand, N.K., McCann, T., Knottenbelt, C.M., Tebb, A.J., Evans, H., Eckersall, P.D., and Ramsey, I.K.
Subjects:S Agriculture > SF Animal culture > SF600 Veterinary Medicine
College/School:College of Medical Veterinary and Life Sciences > School of Veterinary Medicine
College of Medical Veterinary and Life Sciences > Institute of Infection Immunity and Inflammation
Journal Name:Journal of Small Animal Practice
Publisher:Wiley-Blackwell Publishing Ltd.
ISSN:0022-4510
ISSN (Online):1748-5827
Published Online:22 March 2010
Copyright Holders:Copyright © 2010 Wiley-Blackwell
First Published:First published in Journal of Small Animal Practice 51(4):204-209
Publisher Policy:Reproduced in accordance with the copyright policy of the publisher

University Staff: Request a correction | Enlighten Editors: Update this record