The role of the chemokine receptor CXCR4 in infection with feline immunodeficiency virus

Willett, B.J. and Hosie, M.J. (1999) The role of the chemokine receptor CXCR4 in infection with feline immunodeficiency virus. Molecular Membrane Biology, 16(1), pp. 67-72. (doi: 10.1080/096876899294779)

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Infection with feline immunodeficiency virus (FIV) leads to the development of a disease state similar to AIDS in man. Recent studies have identified the chemokine receptor CXCR4 as the major receptor for cell culture-adapted strains of FIV, suggesting that FIV and human immunodeficiency virus (HIV) share a common mechanism of infection involving an interaction between the virus and a member of the seven transmembrane domain superfamily of molecules. This article reviews the evidence for the involvement of chemokine receptors in FIV infection and contrasts these findings with similar studies on the primate lentiviruses HIV and SIV (simian immunodeficiency virus).

Item Type:Articles
Glasgow Author(s) Enlighten ID:Hosie, Professor Margaret and Willett, Professor Brian
Authors: Willett, B.J., and Hosie, M.J.
Subjects:Q Science > QR Microbiology > QR355 Virology
College/School:College of Medical Veterinary and Life Sciences > Institute of Infection Immunity and Inflammation
Journal Name:Molecular Membrane Biology
Journal Abbr.:Mol Membr Biol.
First Published:First published in Molecular Membrane Biology 16(1):67-72
Publisher Policy:Reproduced in accordance with the copyright policy of the publisher.

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