Fowler, L.S., Ellis, D. and Sutherland, A. (2009) Synthesis of fluorescent enone derived α-amino acids. Organic and Biomolecular Chemistry, 7(20), pp. 4309-4316. (doi: 10.1039/b912782h)
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Abstract
The development of a facile and general method for the preparation of enone derived α-amino acids is described. The key step involves a Horner–Wadsworth–Emmons reaction between an aspartic acid derived β-keto phosphonate ester and a range of aldehydes resulting in the formation of highly functionalised α-amino acids in good yields. An efficient two-stage deprotection process using mild conditions was developed to give the parent α-amino acids. Application of this methodology has produced a novel fluorescent α-amino acid that has potential as a biological marker.
Item Type: | Articles |
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Status: | Published |
Refereed: | Yes |
Glasgow Author(s) Enlighten ID: | Sutherland, Professor Andrew |
Authors: | Fowler, L.S., Ellis, D., and Sutherland, A. |
Subjects: | Q Science > QD Chemistry |
College/School: | College of Science and Engineering > School of Chemistry |
Journal Name: | Organic and Biomolecular Chemistry |
ISSN: | 1477-0520 |
ISSN (Online): | 1477-0539 |
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