Genetic variation among lambs in peripheral IgE activity against the larval stages of Teladorsagia circumcincta

Murphy, L., Eckersall, P.D., Bishop, S.C., Pettit, J.J., Huntley, J.F., Burchmore, R.J.S. and Stear, M.J. (2010) Genetic variation among lambs in peripheral IgE activity against the larval stages of Teladorsagia circumcincta. Parasitology, 137(8), pp. 1249-1260. (doi:10.1017/S0031182010000028)

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Abstract

IgA and IgE activity against Teladorsagia circumcincta was investigated in a flock of Texel lambs following natural, mixed nematode infection among lambs. The distribution of IgA activity was similar to a gamma distribution whereas IgE activity was different. Box-Cox analysis demonstrated that X0.25 was a suitable transformation to normalise IgE responses. The transformed IgE activity was under moderate to strong genetic control. Nine different allergens were identified by proteomic analysis. Tropomyosin was selected for further analysis. IgE activity against tropomyosin was moderately heritable and associated with decreased egg counts and with reduced body weight at the time of sampling.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Burchmore, Dr Richard and Eckersall, Professor Peter and Stear, Professor Michael and Murphy, Dr Lisa
Authors: Murphy, L., Eckersall, P.D., Bishop, S.C., Pettit, J.J., Huntley, J.F., Burchmore, R.J.S., and Stear, M.J.
Subjects:Q Science > QR Microbiology
College/School:College of Medical Veterinary and Life Sciences > Institute of Infection Immunity and Inflammation
Journal Name:Parasitology
Publisher:Cambridge University Press
ISSN:0031-1820
ISSN (Online):1469-8161
Published Online:17 March 2010
Copyright Holders:Copyright © 2010 Cambridge University Press
First Published:First published in Parasitology 137(8):1249-1260
Publisher Policy:Reproduced in accordance with the copyright policy of the publisher

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