Vaccination with an Inactivated Virulent Feline Immunodeficiency Virus Engineered to Express High Levels of Env

Hosie, M.J. et al. (2005) Vaccination with an Inactivated Virulent Feline Immunodeficiency Virus Engineered to Express High Levels of Env. Journal of Virology, 79(3), pp. 1954-1957.

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Publisher's URL: http://jvi.asm.org/cgi/reprint/79/3/1954

Abstract

An inactivated virus vaccine was prepared from a pathogenic isolate of feline immunodeficiency virus containing a mutation that eliminated an endocytic sorting signal in the envelope glycoprotein, increasing its expression on virions. Cats immunized with inactivated preparations of this modified virus exhibited strong titers of antibody to Env by enzyme-linked immunosorbent assay. Evidence of protection following challenge demonstrated the potential of this approach to lentiviral vaccination.

Item Type:Articles
Keywords:FIV, HIV, AIDS, vaccine
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Hosie, Professor Margaret and Willett, Professor Brian and Neil, Professor James
Authors: Hosie, M.J., Klein, D., Binley, J.M., Dunsford, T.H., Jarrett, O., Neil, J.C., Knapp, E., Giannecchini, S., Matteucci, D., Bendinelli, M., Hoxie, J.A., and Willett, B.J.
Subjects:S Agriculture > SF Animal culture > SF600 Veterinary Medicine
College/School:College of Medical Veterinary and Life Sciences > Institute of Infection Immunity and Inflammation
Research Group:Retrovirus Research Laboratory
Journal Name:Journal of Virology
Journal Abbr.:J. Virol.
Publisher:American Society for Microbiology
ISSN:0022-538X
ISSN (Online):1098-5514
Copyright Holders:Copyright © 2005 American Society for Microbiology
Publisher Policy:Reproduced in accordance with the copyright policy of the publisher

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