Mapping the domains of CD134 as a functional receptor for feline immunodeficiency virus (FIV)

Willett, B.J., McMonagle, E.L., Bonci, F., Pistello, M. and Hosie, M.J. (2006) Mapping the domains of CD134 as a functional receptor for feline immunodeficiency virus (FIV). Journal of Virology, 80(15), pp. 7744-7747. (doi: 10.1128/JVI.00722-06)



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The feline homologue of CD134 (fCD134) is the primary binding receptor for feline immunodeficiency virus (FIV), targeting the virus preferentially to activated CD4+ helper T cells. However, strains of FIV differ in their utilisation of CD134; the prototypic strain PPR, requires a minimal determinant in CRD1 of fCD134 to confer near optimal receptor function while strains such as GL8 require additional determinants in the CD134 CRD2. We map this determinant to a loop in CRD2 governing the interaction between the receptor and its ligand; substitution of amino acids S78N,S79Y,K80E restored full viral receptor activity to the CDR2 of human CD134 in the context of feline CD134 with tyrosine-79 appearing to be the critical residue for restoration of receptor function.

Item Type:Articles
Keywords:AIDS, FIV, HIV receptor
Glasgow Author(s) Enlighten ID:Hosie, Professor Margaret and Willett, Professor Brian
Authors: Willett, B.J., McMonagle, E.L., Bonci, F., Pistello, M., and Hosie, M.J.
Subjects:S Agriculture > SF Animal culture > SF600 Veterinary Medicine
College/School:College of Medical Veterinary and Life Sciences > Institute of Infection Immunity and Inflammation
Research Group:Retrovirus Research Laboratory
Journal Name:Journal of Virology
Journal Abbr.:J. Virol.
Publisher:American Society for Microbiology
ISSN (Online):1098-5514
Copyright Holders:Copyright © 2006 American Society for Microbiology
First Published:First published in Journal of Virology 80(15):7744-7747
Publisher Policy:Reproduced in accordance with the copyright policy of the publisher

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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
363381Rational Design of a Lentiviral VaccineMargaret HosieMedical Research Council (MRC)G0300387Centre for Virus Research