A comparison of the rate of recovery of 13CO2 in exhaled breath with 2H in body water following ingestion of [2H/13C] octanoic acid in a dog

Wyse, C.A., Yam, P.S., Slater, C., Cooper, J.M. and Preston, T. (2003) A comparison of the rate of recovery of 13CO2 in exhaled breath with 2H in body water following ingestion of [2H/13C] octanoic acid in a dog. Research in Veterinary Science, 74(2), pp. 123-127. (doi: 10.1016/S0034-5288(02)00178-9)

Abstract

The objective of this study was to assess post-gastric processing of octanoic acid (OA) by comparing the rate of recovery of C-13 in breath with the rate of recovery of H-2 in saliva following ingestion of [H-2/C-13]OA. A test meal with 100 mg [C-13]OA and 750 mg [H-2]OA was ingested on two separate occasions by one dog. Exhaled breath and saliva samples were collected at set time points for 6 h following ingestion of the test meal. Two indices were computed, half recovery time (t(1/2)) and the time of peak excretion (t(max)). Recovery of (2) H in saliva was quicker than recovery of C-13 in breath as determined by the difference in the indices for each isotope; 1.33 and 1.59 h for t(1/2) and t(max), respectively. These findings suggest that the post-gastric processing of OA imposes a delay on the recovery of C-13 in breath in the dog, as occurs in man and in the horse.

• Item Type: Articles
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Preston, Professor Tom
• Authors: Wyse, C.A., Yam, P.S., Slater, C., Cooper, J.M., and Preston, T.
• Subjects: S Agriculture > SF Animal culture > SF600 Veterinary Medicine; Q Science > QL Zoology
• College/School: College of Science and Engineering > Scottish Universities Environmental Research Centre
• Journal Name: Research in Veterinary Science
• ISSN: 0034-5288