Development of high-resolution real-time sub-ppb ethane spectroscopy and some pilot studies in life science

Skeldon, K.D., Gibson, G.M. , Wyse, C.A., McMillan, L., Monk, S.D., Longbottom, C. and Padgett, M.J. (2005) Development of high-resolution real-time sub-ppb ethane spectroscopy and some pilot studies in life science. Applied Optics, 44, pp. 4712-4721. (doi: 10.1364/AO.44.004712)

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Abstract

We describe a high-resolution real-time spectroscopy system targeted to ethane gas with sensitivity > or = 70 ppt and response time from > or = 0.7 s. The measurement technique is based on a mid-IR lead-salt laser passing through a Herriott cell through which a gas sample flows. We compare wavelength scanning and locked configurations and discuss their relative merits. The technology has been motivated by clinical breath testing applications, ethane being widely regarded as the most important breath biomarker for cell damage via free-radical-mediated oxidative attack. We discuss preliminary human and animal studies in which ultrasensitive real-time ethane detection offers new diagnostic and monitoring potential.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Gibson, Dr Graham and Wyse, Dr Cathy and Skeldon, Dr Kenneth and Padgett, Professor Miles
Authors: Skeldon, K.D., Gibson, G.M., Wyse, C.A., McMillan, L., Monk, S.D., Longbottom, C., and Padgett, M.J.
College/School:College of Science and Engineering > School of Physics and Astronomy
Journal Name:Applied Optics
ISSN:0003-6935

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