When kinases meet mathematics: the systems biology of MAPK signalling

Kolch, W., Calder, M. and Gilbert, D. (2005) When kinases meet mathematics: the systems biology of MAPK signalling. FEBS Letters, 579(8), pp. 1891-1895. (doi:10.1016/j.febslet.2005.02.002)

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Publisher's URL: http://dx.doi.org/10.1016/j.febslet.2005.02.002

Abstract

The mitogen activated protein kinase/extracellular signal regulated kinase pathway regulates fundamental cellular function such as cell proliferation, survival, differentiation and motility, raising the question how these diverse functions are specified and coordinated. They are encoded through the activation kinetics of the pathway, a multitude of feedback loops, scaffold proteins, subcellular compartmentalisation, and crosstalk with other pathways. These regulatory motifs alone or in combination can generate a multitude of complex behaviour. Systems biology tries to decode this complexity through mathematical modelling and prediction in order to gain a deeper insight into the inner works of signalling networks.

Item Type:Articles
Keywords:Mitogen activated protein kinase/extracellular signal regulated kinase, Signalling networks, Systems biology, Computational modelling
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Calder, Professor Muffy
Authors: Kolch, W., Calder, M., and Gilbert, D.
Subjects:Q Science > QA Mathematics
College/School:College of Science and Engineering > School of Computing Science
Journal Name:FEBS Letters
Publisher:Elsevier
ISSN:0014-5793
Copyright Holders:Copyright © 2005 Elsevier
First Published:First published in FEBS Letters 579(8):1891-1895
Publisher Policy:Reproduced in accordance with the copyright policy of the publisher

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