Lipolysis generates platelet dysfunction after in vivo heparin administration

Muriithi, E.W., Belcher, P.R., Day, S., Chaudhry, M.A., Caslake, M.J. and Wheatley, D.J. (2002) Lipolysis generates platelet dysfunction after in vivo heparin administration. Clinical Science, 103(4), pp. 433-440.

Abstract

Heparin, when administered to patients undergoing operations using cardiopulmonary bypass, induces plasma changes that gradually impair platelet macroaggregation, but heparinization of whole blood in vitro does not have this effect. The plasma changes induced by heparin in vivo continue to progress in whole blood ex vivo. Heparin releases several endothelial proteins, including lipoprotein lipase, hepatic lipase, platelet factor-4 and superoxide dismutase. These enzymes, which remain active in plasma ex vivo, may impair platelet macroaggregation after in vivo heparinization and during cardiopulmonary bypass.

• Item Type: Articles
• Keywords: cardiac surgery, hirudin, impedance aggregometry, lipase, lipoprotein.
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Belcher, PR and Caslake, Professor Muriel and Wheatley, Professor David
• Authors: Muriithi, E.W., Belcher, P.R., Day, S., Chaudhry, M.A., Caslake, M.J., and Wheatley, D.J.
• Subjects: R Medicine > RC Internal medicine
• College/School: College of Medical Veterinary and Life Sciences
• Journal Name: Clinical Science
• Publisher: Portland Press
• ISSN: 0143-5221
• Copyright Holders: Copyright © 2002 Portland Press
• First Published: First published in Clinical Science 103(4):433-40
• Publisher Policy: Reproduced in accordance with the copyright policy of the publisher