Absence of detection of varicella-zoster virus DNA in temporal artery biopsies obtained from patients with giant cell arteritis

Kennedy, P.G.E., Grinfield, E. and Esiri, M.M. (2003) Absence of detection of varicella-zoster virus DNA in temporal artery biopsies obtained from patients with giant cell arteritis. Journal of the Neurological Sciences, 215(1-2), pp. 27-29. (doi: 10.1016/S0022-510X(03)00167-9)

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Abstract

It has been suggested that Varicella-Zoster virus (VZV) may play a role in the pathogenesis of giant cell arteritis (GCA). We therefore used both in situ hybridisation and in situ Polymerase Chain Reaction amplification techniques in an attempt to identify VZV DNA in 15 temporal arteries from histologically proven GCA. We did not detect evidence of VZV DNA in the arteries of any of these subjects, nor in temporal arteries obtained from seven normal control subjects. VZV was detected, however, in neurons in a human trigeminal ganglion. While sampling variation and sensitivity issues are likely to play a role in the discrepancies observed in different studies of VZV in GCA, this study does not provide further support for the notion that VZV is playing a significant part in causing GCA.

Item Type:Articles
Keywords:Varicella-Zoster virus, giant cell arteritis, in situ hybridisation, temporal artery
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Kennedy, Professor Peter
Authors: Kennedy, P.G.E., Grinfield, E., and Esiri, M.M.
Subjects:R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
College/School:College of Medical Veterinary and Life Sciences
College of Medical Veterinary and Life Sciences > Institute of Infection Immunity and Inflammation
Journal Name:Journal of the Neurological Sciences
Publisher:Elsevier
ISSN:0022-510X
ISSN (Online):1878-5883

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