A genetic TRP down the channel to praziquantel resistance

Cotton, J. A. and Doyle, S. R. (2022) A genetic TRP down the channel to praziquantel resistance. Trends in Parasitology, 38(5), pp. 351-352. (doi: 10.1016/j.pt.2022.02.006) (PMID:35246385)

Abstract

The anthelmintic praziquantel (PZQ) is an essential tool in controlling schistosomiasis, so reports of reduced PZQ efficacy are of great public health concern. Le Clec'h et al. recently identified a gene responsible for PZQ resistance in experimentally selected resistant Schistosoma mansoni. The importance of this locus in natural infections remains to be established.

• Item Type: Articles
• Additional Information: We are supported by the Wellcome Trust via their core funding of the Wellcome Trust Sanger Institute [grant 108413/A/15/D] and a UKRI Future Leaders Fellowship [MR/T020733/1] to S.R.D.
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Cotton, Professor James
• Authors: Cotton, J. A., and Doyle, S. R.
• College/School: College of Medical Veterinary and Life Sciences > School of Biodiversity, One Health & Veterinary Medicine
• Journal Name: Trends in Parasitology
• Publisher: Elsevier (Cell Press)
• ISSN: 1471-4922
• ISSN (Online): 1471-5007
• Published Online: 01 March 2022
• Copyright Holders: Copyright © 2022 Elsevier Ltd.
• First Published: First published in Trends in Parasitology 38(5):351-352
• Publisher Policy: Reproduced in accordance with the publisher copyright policy