Two years into the COVID-19 pandemic: lessons learned

da Silva, S. J. R. et al. (2022) Two years into the COVID-19 pandemic: lessons learned. ACS Infectious Diseases, 8(9), pp. 1758-1814. (doi: 10.1021/acsinfecdis.2c00204) (PMID:35940589) (PMCID:PMC9380879)

Abstract

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a highly transmissible and virulent human-infecting coronavirus that emerged in late December 2019 in Wuhan, China, causing a respiratory disease called coronavirus disease 2019 (COVID-19), which has massively impacted global public health and caused widespread disruption to daily life. The crisis caused by COVID-19 has mobilized scientists and public health authorities across the world to rapidly improve our knowledge about this devastating disease, shedding light on its management and control, and spawned the development of new countermeasures. Here we provide an overview of the state of the art of knowledge gained in the last 2 years about the virus and COVID-19, including its origin and natural reservoir hosts, viral etiology, epidemiology, modes of transmission, clinical manifestations, pathophysiology, diagnosis, treatment, prevention, emerging variants, and vaccines, highlighting important differences from previously known highly pathogenic coronaviruses. We also discuss selected key discoveries from each topic and underline the gaps of knowledge for future investigations.

• Item Type: Articles
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Kohl, Professor Alain
• Authors: da Silva, S. J. R., Frutuoso do Nascimento, J. C., Mendes, R. P. G., Guarines, K. M., da Silva, C. T. A., da Silva, P. G., de Magalhães, J. J. F., Vigaar, J. R.J., Silva-Júnior, A., Kohl, A., Pardee, K., and Pena, L.
• College/School: College of Medical Veterinary and Life Sciences > School of Infection & Immunity > Centre for Virus Research
• Journal Name: ACS Infectious Diseases
• Publisher: American Chemical Society
• ISSN: 2373-8227
• ISSN (Online): 2373-8227
• Published Online: 08 August 2022
• Copyright Holders: Copyright © 2022 The Authors
• First Published: First published in ACS Infectious Diseases 8(9): 1758-1814
• Publisher Policy: Reproduced under a Creative Commons License

Project Code	Award No	Project Name	Principal Investigator	Funder's Name	Funder Ref	Lead Dept
172630007		Arthropod-borne infections and emerging virus infections in high risk areas (Programme 4)	Alain Kohl	Medical Research Council (MRC)	MC_UU_12014/8	III - Centre for Virus Research