Immune responses in baboons vaccinated with HIV-2 genetic expression libraries

Blackbourn, D. (2002) Immune responses in baboons vaccinated with HIV-2 genetic expression libraries. Journal of Medical Primatology, 31(6), pp. 323-329. (doi: 10.1034/j.1600-0684.2002.01035.x)

Full text not currently available from Enlighten.


Immunization using genetic expression libraries may be an improvement over conventional DNA immunization using a single gene because more epitopes are simultaneously presented to the immune system. In this study, we evaluated the effectiveness of an HIV-2 vaccine made from a genomic expression library in baboons. We found that HIV-2 expression library immunization induced HIV-2-specific memory responses but low levels of CD8+ cell anti-viral responses and neutralizing antibodies. After intravenous virus challenge using a homologous pathogenic variant, HIV-2UC2/9429, viral loads were similar in the HIV-2-immunized and control baboons. We conclude that although immunization using HIV-2 expression libraries induces immune responses, this approach does not provide protection in baboons against intravenous challenge with HIV-2.

Item Type:Articles
Glasgow Author(s) Enlighten ID:UNSPECIFIED
Authors: Blackbourn, D.
College/School:College of Medical Veterinary and Life Sciences
Journal Name:Journal of Medical Primatology
Published Online:09 December 2002

University Staff: Request a correction | Enlighten Editors: Update this record