Thompson, E. J. et al. (2022) Long COVID burden and risk factors in 10 UK longitudinal studies and electronic health records. Nature Communications, 13, 3528. (doi: 10.1038/s41467-022-30836-0) (PMID:35764621) (PMCID:PMC9240035)
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Abstract
The frequency of, and risk factors for, long COVID are unclear among community-based individuals with a history of COVID-19. To elucidate the burden and possible causes of long COVID in the community, we coordinated analyses of survey data from 6907 individuals with self-reported COVID-19 from 10 UK longitudinal study (LS) samples and 1.1 million individuals with COVID-19 diagnostic codes in electronic healthcare records (EHR) collected by spring 2021. Proportions of presumed COVID-19 cases in LS reporting any symptoms for 12+ weeks ranged from 7.8% and 17% (with 1.2 to 4.8% reporting debilitating symptoms). Increasing age, female sex, white ethnicity, poor pre-pandemic general and mental health, overweight/obesity, and asthma were associated with prolonged symptoms in both LS and EHR data, but findings for other factors, such as cardio-metabolic parameters, were inconclusive.
Item Type: | Articles |
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Additional Information: | ** From Springer Nature via Jisc Publications Router ** History: received 22-09-2021; accepted 19-05-2022; registration 23-05-2022; pub-electronic 28-06-2022; online 28-06-2022; collection 12-2022. ** Licence for this article: http://creativecommons.org/licenses/by/4.0/ |
Keywords: | Article, /692/699/255/2514, /692/499, /692/308/174, /631/326/596/4130, article |
Status: | Published |
Refereed: | Yes |
Glasgow Author(s) Enlighten ID: | Katikireddi, Professor Vittal and Green, Dr Michael and Niedzwiedz, Dr Claire |
Authors: | Thompson, E. J., Williams, D. M., Walker, A. J., Mitchell, R. E., Niedzwiedz, C. L., Yang, T. C., Huggins, C. F., Kwong, A. S. F., Silverwood, R. J., Di Gessa, G., Bowyer, R. C. E., Northstone, K., Hou, B., Green, M. J., Dodgeon, B., Doores, K. J., Duncan, E. L., Williams, F. M. K., Steptoe, A., Porteous, D. J., McEachan, R. R. C., Tomlinson, L., Goldacre, B., Patalay, P., Ploubidis, G. B., Katikireddi, S. V., Tilling, K., Rentsch, C. T., Timpson, N. J., Chaturvedi, N., and Steves, C. J. |
College/School: | College of Medical Veterinary and Life Sciences > School of Health & Wellbeing > General Practice and Primary Care College of Medical Veterinary and Life Sciences > School of Health & Wellbeing > MRC/CSO SPHSU |
Journal Name: | Nature Communications |
Publisher: | Nature Research |
ISSN: | 2041-1723 |
ISSN (Online): | 2041-1723 |
Copyright Holders: | Copyright © 2022 The Authors |
First Published: | First published in Nature Communications 13: 3528 |
Publisher Policy: | Reproduced under a Creative Commons License |
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