Prospective cohort study reveals unexpected aetiologies of livestock abortion in Northern Tanzania

Thomas, K. M. et al. (2022) Prospective cohort study reveals unexpected aetiologies of livestock abortion in Northern Tanzania. Scientific Reports, 12, 11669. (doi: 10.1038/s41598-022-15517-8) (PMID:35803982) (PMCID:PMC9270399)

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Abstract

Livestock abortion is an important cause of productivity losses worldwide and many infectious causes of abortion are zoonotic pathogens that impact on human health. Little is known about the relative importance of infectious causes of livestock abortion in Africa, including in subsistence farming communities that are critically dependent on livestock for food, income, and wellbeing. We conducted a prospective cohort study of livestock abortion, supported by cross-sectional serosurveillance, to determine aetiologies of livestock abortions in livestock in Tanzania. This approach generated several important findings including detection of a Rift Valley fever virus outbreak in cattle; high prevalence of C. burnetii infection in livestock; and the first report of Neospora caninum, Toxoplasma gondii, and pestiviruses associated with livestock abortion in Tanzania. Our approach provides a model for abortion surveillance in resource-limited settings. Our findings add substantially to current knowledge in sub-Saharan Africa, providing important evidence from which to prioritise disease interventions.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:MMBAGA, Professor Blandina Theoph and Willett, Professor Brian and Halliday, Dr Jo and Allan, Dr Kathryn and De Glanville, Dr William and Innes, Professor Elisabeth and Carter, Mr Ryan and Claxton, Dr John and Thomas, Dr Kate and Lankester, Dr Felix and Russell, Dr George and Wheelhouse, Dr Nick and Dagleish, Dr Mark and Millins, Dr Caroline and Cleaveland, Professor Sarah and Chapman, Gail
Authors: Thomas, K. M., Kibona, T., Claxton, J. R., de Glanville, W. A., Lankester, F., Amani, N., Buza, J. J., Carter, R. W., Chapman, G. E., Crump, J. A., Dagleish, M. P., Halliday, J. E.B., Hamilton, C. M., Innes, E. A., Katzer, F., Livingstone, M., Longbottom, D., Millins, C., Mmbaga, B. T., Mosha, V., Nyarobi, J., Nyasebwa, O. M., Russell, G. C., Sanka, P. N., Semango, G., Wheelhouse, N., Willett, B. J., Cleaveland, S., and Allan, K. J.
College/School:College of Medical Veterinary and Life Sciences > School of Biodiversity, One Health & Veterinary Medicine
College of Medical Veterinary and Life Sciences > School of Infection & Immunity > Centre for Virus Research
Journal Name:Scientific Reports
Publisher:Nature Research
ISSN:2045-2322
ISSN (Online):2045-2322
Copyright Holders:Copyright © 2022 The Authors
First Published:First published in Scientific Reports 12: 11669
Publisher Policy:Reproduced under a Creative Commons License

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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
190437Impact, ecology and social determinants of bacterial zoonoses in northern TanzaniaSarah CleavelandBiotechnology and Biological Sciences Research Council (BBSRC)BB/J010367/1Institute of Biodiversity, Animal Health and Comparative Medicine
190825Social, economic and environmental drivers of zoonoses in Tanzania (SEEDZ)Sarah CleavelandBiotechnology and Biological Sciences Research Council (BBSRC)BB/L018926/1Institute of Biodiversity, Animal Health and Comparative Medicine