Insall, R. H. , Paschke, P. and Tweedy, L. (2022) Steering yourself by the bootstraps: how cells create their own gradients for chemotaxis. Trends in Cell Biology, 32(7), pp. 585-596. (doi: 10.1016/j.tcb.2022.02.007) (PMID:35351380)
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Abstract
Chemotaxis, where cell movement is steered by chemical gradients, is a widespread and essential way of organising cell behaviour. But where do the instructions come from – who makes gradients, and how are they controlled? We discuss the emerging concept that chemotactic cells often create attractant gradients at the same time as responding to them. This self-guidance is more robust, works across greater distances, and is more informative about the local environment than passive responses. Several mechanisms can establish autonomous gradients. Best known are self-generated gradients, in which the cells degrade a widespread attractant, but cells also produce repellents and ‘relay’ by secreting fresh attractant after stimulation. Understanding how cells make and interpret their own chemoattractant gradients is fundamental to understanding the spatial patterns seen in all organisms.
Item Type: | Articles |
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Additional Information: | This work was funded by Cancer Research UK (grant number A24450) and the Wellcome Trust (grant number 221786). |
Status: | Published |
Refereed: | Yes |
Glasgow Author(s) Enlighten ID: | Tweedy, Dr Luke and Insall, Professor Robert and Paschke, Dr Peggy |
Authors: | Insall, R. H., Paschke, P., and Tweedy, L. |
College/School: | College of Medical Veterinary and Life Sciences College of Medical Veterinary and Life Sciences > School of Cancer Sciences |
Journal Name: | Trends in Cell Biology |
Publisher: | Elsevier (Cell Press) |
ISSN: | 0962-8924 |
ISSN (Online): | 1879-3088 |
Published Online: | 26 March 2022 |
Copyright Holders: | Copyright © 2022 The Authors |
First Published: | First published in Trends in Cell Biology 32(7):585-596 |
Publisher Policy: | Reproduced under a Creative Commons License |
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