Genome sequence of the aurodox-producing bacterium Streptomyces goldiniensis ATCC 21386

McHugh, R. E. , Munnoch, J. T., Roe, A. J. and Hoskisson, P. A. (2022) Genome sequence of the aurodox-producing bacterium Streptomyces goldiniensis ATCC 21386. Access Microbiology, 4(5), 000358. (doi: 10.1099/acmi.0.000358) (PMID:36003359) (PMCID:PMC9394534)

Abstract

We report the genome sequence of Streptomyces goldiniensis ATCC 21386, a strain which produces the anti-bacterial and anti-virulence polyketide, aurodox. The genome of S. goldiniensis ATCC 21386 was sequenced using a multiplatform hybrid approach, revealing a linear genome of ~10 Mbp with a G+C content of 71%. The genome sequence revealed 36 putative biosynthetic gene clusters (BGCs), including a large region of 271 Kbp that was rich in biosynthetic capability. The genome sequence is deposited in DDBJ/EMBL/GenBank with the accession number PRJNA602141.

• Item Type: Articles
• Additional Information: We would like to thank the University of Strathclyde and University of Glasgow for jointly funding the PhD of REM. PAH would also like to acknowledge funding from BBSRC (BB/T001038/1 and BB/T004126/1) and the Royal Academy of Engineering Research Chair Scheme for long term personal research support (RCSRF2021\11\15). AJR and PAH would like to acknowledge funding from MRC (MR/V011499/1).
• Keywords: General Materials Science
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Roe, Professor Andrew and McHugh, Dr Rebecca
• Authors: McHugh, R. E., Munnoch, J. T., Roe, A. J., and Hoskisson, P. A.
• College/School: College of Medical Veterinary and Life Sciences > School of Infection & Immunity
• Journal Name: Access Microbiology
• Publisher: Microbiology Society
• ISSN: 2516-8290
• ISSN (Online): 2516-8290
• Published Online: 30 May 2022
• Copyright Holders: Copyright © The Author(s) 2022
• First Published: First published in Access Microbiology 4(5): 000358
• Publisher Policy: Reproduced under a Creative Commons License

Project Code	Award No	Project Name	Principal Investigator	Funder's Name	Funder Ref	Lead Dept
311034		Aversion Therapy for Bacteria: Repurposing Aurodox	Andrew Roe	Medical Research Council (MRC)	MR/V011499/1	Chemistry