Think global but act local: Tuning the dendritic cell response in cancer

Bravo-Blas, A., Pirillo, C., Shergold, A., Andrusaite, A. and Roberts, E. W. (2022) Think global but act local: Tuning the dendritic cell response in cancer. International Journal of Biochemistry and Cell Biology, 147, 106227. (doi: 10.1016/j.biocel.2022.106227) (PMID:35605877)

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Abstract

Despite their low abundance in tumours conventional dendritic cells play an outsized role in initiating and perpetuating anti-tumour immunity; however progressively growing tumours suppress dendritic cell function in a range of ways preventing effective anti-tumour T cell responses. While the success of immune checkpoint blockade has focused attention on T-cell directed therapies, activating tumour dendritic cells has been shown to be critical for the efficacy of several immunotherapies and other conventional therapies owing to their ability to activate and restimulate anti-tumour T-cells. As such, the importance of understanding the mechanisms by which dendritic cell function is impaired are being investigated further. Yet, while much attention has been paid to the tumour microenvironment less has been given to the macroenvironment including effects in the bone marrow and the lymph node. It is now clear that dendritic cell function can be impaired in a variety of ways at different anatomical sites and understanding these mechanisms will be critical for developing effective strategies to tune the dendritic cell response in cancer.

Item Type:Articles
Additional Information:Cancer Research UK, United Kingdom, A_BICR_1920_Roberts.
Keywords:Lymph nodes, Tumour draining, Antigen transfer
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Roberts, Dr Ed and Andrusaite, Ms Anna and Shergold, Miss Amy and Bravo-Blas, Dr Alberto
Authors: Bravo-Blas, A., Pirillo, C., Shergold, A., Andrusaite, A., and Roberts, E. W.
College/School:College of Medical Veterinary and Life Sciences > School of Cancer Sciences
College of Medical Veterinary and Life Sciences > School of Infection & Immunity
Journal Name:International Journal of Biochemistry and Cell Biology
Publisher:Elsevier
ISSN:1357-2725
ISSN (Online):1878-5875
Published Online:20 May 2022

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