Association between simian virus 40 DNA and lymphoma in the United Kingdom

MacKenzie, J., Wilson, K.S., Perry, J., Gallagher, A. and Jarrett, R.F. (2003) Association between simian virus 40 DNA and lymphoma in the United Kingdom. Journal of the National Cancer Institute, 95(13), pp. 1001-1003.

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Abstract

Recent studies have reported the presence of simian virus 40 (SV40) DNA sequences in approximately 40% of tumor samples from non-Hodgkin’s lymphoma (NHL) patients from the United States. We examined a series of 259 tumor and blood samples, including 152 NHL samples, from patients in the U.K. with lymphadenopathy and lymphoid leukemia for the presence of SV40 DNA using a highly sensitive quantitative polymerase chain reaction (PCR) assay and a consensus PCR assay capable of detecting the polyomaviruses SV40, BK, and JC. SV40 DNA sequences were not detected in any sample using either assay. Because the incidence of NHL is similar in the U.K. and the United States, this finding suggests that SV40 is unlikely to have an etiologic role in NHL.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Jarrett, Professor Ruth and Gallagher, Dr Alice and MacKenzie, Dr Jane
Authors: MacKenzie, J., Wilson, K.S., Perry, J., Gallagher, A., and Jarrett, R.F.
College/School:University Services > Learning and Teaching Services Division
College of Medical Veterinary and Life Sciences > Institute of Infection Immunity and Inflammation
Journal Name:Journal of the National Cancer Institute
Journal Abbr.:JNCI
Publisher:Oxford University Press
ISSN:0027-8874
ISSN (Online):1460-2105

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