Viruses and Hodgkin disease: No evidence of novel herpesviruses in non-EBV-associated lesions

Gallagher, A., Perry, J., Shield, L., Freeland, J., MacKenzie, J. and Jarrett, R.F. (2002) Viruses and Hodgkin disease: No evidence of novel herpesviruses in non-EBV-associated lesions. International Journal of Cancer, 101(3), pp. 259-264. (doi:10.1002/ijc.10603)

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Abstract

The Epstein-Barr virus (EBV) is associated with a proportion of cases of Hodgkin disease (HD) and this association is believed to be causal. Epidemiological studies suggest that an infectious agent is involved in the aetiology of young adult HD, however, cases in this age group are less likely to have EBV-associated disease than cases diagnosed in early childhood or older adult years. Molecular studies have failed to find a consistent association between HD and other candidate viruses, and the aetiology of non-EBV-associated cases remains obscure. We looked for evidence of herpesvirus infection in samples of non-EBV-associated HD using a highly sensitive, degenerate PCR assay. Despite exhaustive sequence analysis of PCR products, no novel herpesviruses were identified. These results suggest that it is extremely unlikely that a novel herpesvirus is involved in the pathogenesis of non-EBV-associated HD.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Jarrett, Professor Ruth and Gallagher, Dr Alice and Shield, Ms Lesley
Authors: Gallagher, A., Perry, J., Shield, L., Freeland, J., MacKenzie, J., and Jarrett, R.F.
College/School:University Services > Learning and Teaching Services Division
College of Medical Veterinary and Life Sciences > Institute of Infection Immunity and Inflammation
Journal Name:International Journal of Cancer
Journal Abbr.:Int J Cancer
Publisher:John Wiley and Sons
ISSN:0020-7136
ISSN (Online):1097-0215
Published Online:06 August 2002

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