Involvement of apolipoprotein E in herpes simplex encephalitis

Nicoll, J.A., Martin, L., Stewart, J., Murray, L.S., Love, S. and Kennedy, P.G.E. (2001) Involvement of apolipoprotein E in herpes simplex encephalitis. NeuroReport, 12(4), pp. 695-698.

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Abstract

<i>APOE</i> polymorphism may influence risk for cold sores and, by interacting with latent HSV-1, risk for Alzheimer's disease (AD). <i>APOE</i> genotype also influences outcome after brain injury. We sought to determine whether APOE genotype influences risk for herpes simplex encephalitis (HSE), whether apoE is involved in the response to HSE and if <i>APOE</i> genotype influences outcome from HSE. There was increased immunoreactivity of neurons, neuropil and glia for apoE areas of brain damaged by HSE. <i>APOE</i> genotypes for cases of HSE (n = 57) were similar to those of controls (n = 41). <i>APOE</i> genotypes for survivors of HSE were similar to those of patients who died. We conclude that apoE is involved in the response to damage associated with HSE, as in other forms of brain injury. However, <i>APOE</i> genotype does not appear to influence either the risk of developing HSE or subsequent mortality.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Murray, Dr Lilian and Kennedy, Professor Peter
Authors: Nicoll, J.A., Martin, L., Stewart, J., Murray, L.S., Love, S., and Kennedy, P.G.E.
Subjects:R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
College/School:College of Medical Veterinary and Life Sciences > Institute of Infection Immunity and Inflammation
College of Medical Veterinary and Life Sciences > School of Veterinary Medicine
Journal Name:NeuroReport
Publisher:Lippincott Williams & Wilkins
ISSN:0959-4965
ISSN (Online):1473-558X

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