Involvement of apolipoprotein E in herpes simplex encephalitis

Nicoll, J.A., Martin, L., Stewart, J., Murray, L.S., Love, S. and Kennedy, P.G.E. (2001) Involvement of apolipoprotein E in herpes simplex encephalitis. NeuroReport, 12(4), pp. 695-698.

Abstract

<i>APOE</i> polymorphism may influence risk for cold sores and, by interacting with latent HSV-1, risk for Alzheimer's disease (AD). <i>APOE</i> genotype also influences outcome after brain injury. We sought to determine whether APOE genotype influences risk for herpes simplex encephalitis (HSE), whether apoE is involved in the response to HSE and if <i>APOE</i> genotype influences outcome from HSE. There was increased immunoreactivity of neurons, neuropil and glia for apoE areas of brain damaged by HSE. <i>APOE</i> genotypes for cases of HSE (n = 57) were similar to those of controls (n = 41). <i>APOE</i> genotypes for survivors of HSE were similar to those of patients who died. We conclude that apoE is involved in the response to damage associated with HSE, as in other forms of brain injury. However, <i>APOE</i> genotype does not appear to influence either the risk of developing HSE or subsequent mortality.

• Item Type: Articles
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Murray, Dr Lilian and Kennedy, Professor Peter
• Authors: Nicoll, J.A., Martin, L., Stewart, J., Murray, L.S., Love, S., and Kennedy, P.G.E.
• Subjects: R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
• College/School: College of Medical Veterinary and Life Sciences > School of Biodiversity, One Health & Veterinary Medicine; College of Medical Veterinary and Life Sciences > School of Infection & Immunity
• Journal Name: NeuroReport
• Publisher: Lippincott Williams & Wilkins
• ISSN: 0959-4965
• ISSN (Online): 1473-558X