Pawson, P., Nolan, A.M., Reid, J., Boyd, J.S. and Paterson, C. (2002) Changes in the Doppler waveform of the ovine femoral artery following infusion of vasoactive agents: a preliminary study. Research in Veterinary Science, 73(3), pp. 215-221. (doi: 10.1016/S0034-5288(02)00009-7)
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Abstract
The aim of this study was to investigate whether femoral artery pulsatility index (pi) can be used as an indicator of vasomotor tone in the digit of an ungulate species by measuring the change in pi induced by infusion of vasoactive agents in halothane-anaesthetised sheep. Intra-arterial infusion of the vasoconstrictor phenylephrine (9 μg min−1) tended to increase waveform pi (3.89–6.24, n=4, P=0.100). Infusion of a low dose (3 μg min−1) of the vasodilator sodium nitroprusside did not alter femoral artery pi, however infusion of a higher dose (30 μg min−1) tended to increase pi (5.39–6.70, n=5, P=0.059). During these studies heart rate, mean abp and paCO2 did not change significantly. The tendency for pi to increase in response to vasodilation was unexpected and the mechanism involved is unclear. It appears that femoral artery pi cannot be used to predict vasomotor tone in the digit of the anaesthetised sheep.
| Item Type: | Articles |
|---|---|
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Nolan, Professor Andrea and Pawson, Dr Pat and Reid, Professor Jacky |
| Authors: | Pawson, P., Nolan, A.M., Reid, J., Boyd, J.S., and Paterson, C. |
| College/School: | College of Medical Veterinary and Life Sciences > School of Biodiversity, One Health & Veterinary Medicine |
| Journal Name: | Research in Veterinary Science |
| ISSN: | 0034-5288 |
| Published Online: | 29 October 2002 |
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