Global genome diversity of the Leishmania donovani complex

Franssen, S. U. et al. (2020) Global genome diversity of the Leishmania donovani complex. eLife, 9, e51243. (doi: 10.7554/elife.51243) (PMID:32209228) (PMCID:PMC7105377)

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Abstract

Protozoan parasites of the Leishmania donovani complex – L. donovani and L. infantum – cause the fatal disease visceral leishmaniasis. We present the first comprehensive genome-wide global study, with 151 cultured field isolates representing most of the geographical distribution. L. donovani isolates separated into five groups that largely coincide with geographical origin but vary greatly in diversity. In contrast, the majority of L. infantum samples fell into one globally-distributed group with little diversity. This picture is complicated by several hybrid lineages. Identified genetic groups vary in heterozygosity and levels of linkage, suggesting different recombination histories. We characterise chromosome-specific patterns of aneuploidy and identified extensive structural variation, including known and suspected drug resistance loci. This study reveals greater genetic diversity than suggested by geographically-focused studies, provides a resource of genomic variation for future work and sets the scene for a new understanding of the evolution and genetics of the Leishmania donovani complex.

Item Type:Articles
Additional Information:Wellcome Trust (Wellcome Sanger Institute core funding, WT098051, WT206194), EU Framework Programme for Research and Innovation (FP7- 222895).
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Cotton, Professor James
Creator Roles:
Cotton, J. A.Conceptualization, Formal analysis, Supervision, Funding acquisition, Validation, Visualization, Writing – original draft, Project administration
Authors: Franssen, S. U., Durrant, C., Stark, O., Moser, B., Downing, T., Imamura, H., Dujardin, J.-C., Sanders, M. J., Mauricio, I., Miles, M. A., Schnur, L. F., Jaffe, C. L., Nasereddin, A., Schallig, H., Yeo, M., Bhattacharyya, T., Schonian, G., and Cotton, J. A.
College/School:College of Medical Veterinary and Life Sciences > School of Biodiversity, One Health & Veterinary Medicine
Journal Name:eLife
Publisher:eLife Sciences Publications
ISSN:2050-084X
ISSN (Online):2050-084X
Copyright Holders:Copyright © Franssen et al.
First Published:First published in eLife 9:e51243
Publisher Policy:Reproduced under a Creative Commons license

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