Boonpor, J., Parra-Soto, S., Petermann-Rocha, F., Ho, F., Celis-Morales, C. and Gray, S. R. (2022) Combined association of walking pace and grip strength with incident type 2 diabetes. Scandinavian Journal of Medicine and Science in Sports, 32(9), pp. 1356-1365. (doi: 10.1111/sms.14197) (PMID:35612725)
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Abstract
The current study aims to investigate the combined association of walking pace and grip strength with incident type 2 diabetes (T2D). A total of 205 738 participants (mean age 56.6 ± 8.1 years, 115 139 [56.0%] women) without diagnosed or unknown diabetes at baseline from the UK Biobank study were included in this prospective study. Walking pace was self-reported as slow, average, or brisk. Grip strength was measured using a dynamometer and classified as weak, average, and strong. The combined association of walking pace and grip strength with incident T2D was investigated using Cox-proportional hazards models with a 2-year landmark analysis. The additive interaction was conducted by estimating relative excess risk due to interaction (RERI). After the median follow-up period of 5.4 years (interquartile range: 4.8–6.5), 5082 (2.5%) participants were diagnosed with T2D. Compared to brisk-strong individuals (reference group), people who were slow-weak had a higher risk of T2D (hazard ratio: 1.64 [95% CI, 1.42–1.89]) after adjusting for all covariates. There were dose–response gradients across both walking pace and grip strength variables. There was a modest amount of negative additive interaction (RERI; −0.06 [95% CI, −0.16; −0.01]. To conclude, slower pace and weaker grip strength were associated with a higher risk of developing T2D, independent of sociodemographics, lifestyle, and adiposity. Combining walking pace and grip strength might be a practical approach to screening people who are at increased risk of developing T2D.
Item Type: | Articles |
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Status: | Published |
Refereed: | Yes |
Glasgow Author(s) Enlighten ID: | Ho, Dr Frederick and Celis, Dr Carlos and Gray, Professor Stuart and Boonpor, Jirapitcha and Parra, Solange and Petermann-Rocha, Mrs Fanny |
Authors: | Boonpor, J., Parra-Soto, S., Petermann-Rocha, F., Ho, F., Celis-Morales, C., and Gray, S. R. |
College/School: | College of Medical Veterinary and Life Sciences > School of Cardiovascular & Metabolic Health College of Medical Veterinary and Life Sciences > School of Health & Wellbeing > Public Health |
Journal Name: | Scandinavian Journal of Medicine and Science in Sports |
Publisher: | Wiley |
ISSN: | 0905-7188 |
ISSN (Online): | 1600-0838 |
Published Online: | 25 May 2022 |
Copyright Holders: | Copyright © 2022 The Authors |
First Published: | First published in Scandinavian Journal of Medicine and Science in Sports 32(9): 1356-1365 |
Publisher Policy: | Reproduced under a Creative Commons Licence |
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