Combined association of walking pace and grip strength with incident type 2 diabetes

Boonpor, J., Parra-Soto, S., Petermann-Rocha, F., Ho, F., Celis-Morales, C. and Gray, S. R. (2022) Combined association of walking pace and grip strength with incident type 2 diabetes. Scandinavian Journal of Medicine and Science in Sports, (doi: 10.1111/sms.14197) (PMID:35612725) (Early Online Publication)

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Abstract

The current study aims to investigate the combined association of walking pace and grip strength with incident type 2 diabetes (T2D). A total of 205 738 participants (mean age 56.6 ± 8.1 years, 115 139 [56.0%] women) without diagnosed or unknown diabetes at baseline from the UK Biobank study were included in this prospective study. Walking pace was self-reported as slow, average, or brisk. Grip strength was measured using a dynamometer and classified as weak, average, and strong. The combined association of walking pace and grip strength with incident T2D was investigated using Cox-proportional hazards models with a 2-year landmark analysis. The additive interaction was conducted by estimating relative excess risk due to interaction (RERI). After the median follow-up period of 5.4 years (interquartile range: 4.8–6.5), 5082 (2.5%) participants were diagnosed with T2D. Compared to brisk-strong individuals (reference group), people who were slow-weak had a higher risk of T2D (hazard ratio: 1.64 [95% CI, 1.42–1.89]) after adjusting for all covariates. There were dose–response gradients across both walking pace and grip strength variables. There was a modest amount of negative additive interaction (RERI; −0.06 [95% CI, −0.16; −0.01]. To conclude, slower pace and weaker grip strength were associated with a higher risk of developing T2D, independent of sociodemographics, lifestyle, and adiposity. Combining walking pace and grip strength might be a practical approach to screening people who are at increased risk of developing T2D.

Item Type:Articles
Status:Early Online Publication
Refereed:Yes
Glasgow Author(s) Enlighten ID:Celis, Dr Carlos and Gray, Dr Stuart and Ho, Dr Frederick and Petermann-Rocha, Mrs Fanny and Parra, Solange and Boonpor, Jirapitcha
Authors: Boonpor, J., Parra-Soto, S., Petermann-Rocha, F., Ho, F., Celis-Morales, C., and Gray, S. R.
College/School:College of Medical Veterinary and Life Sciences > Institute of Cardiovascular and Medical Sciences
College of Medical Veterinary and Life Sciences > Institute of Health and Wellbeing > Public Health
Journal Name:Scandinavian Journal of Medicine and Science in Sports
Publisher:Wiley
ISSN:0905-7188
ISSN (Online):1600-0838
Published Online:25 May 2022
Copyright Holders:Copyright © 2022 The Authors
First Published:First published in Scandinavian Journal of Medicine and Science in Sports 2022
Publisher Policy:Reproduced under a Creative Commons Licence

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