Cardiac remodelling part 2: clinical, imaging and laboratory findings: a review from the Biomarkers Working Group of the Heart Failure Association of the ESC

Aimo, A. et al. (2022) Cardiac remodelling part 2: clinical, imaging and laboratory findings: a review from the Biomarkers Working Group of the Heart Failure Association of the ESC. European Journal of Heart Failure, 24(6), pp. 944-958. (doi: 10.1002/ejhf.2522) (PMID:35488811)

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Abstract

In patients with heart failure (HF), the beneficial effects of drug and device therapies counteract to some extent ongoing cardiac damage. According to the net balance between these two factors, cardiac geometry and function may improve (reverse remodelling, RR) and even completely normalize (remission), or vice versa progressively deteriorate (adverse remodelling, AR). RR or remission predict a better prognosis, while AR has been associated with worsening clinical status and outcomes. The remodelling process ultimately involves all cardiac chambers, but has been traditionally evaluated in terms of left ventricular volumes and ejection fraction. This is the second part of a review paper by the Biomarker Study Group of the Heart Failure Association of the European Society of Cardiology dedicated to ventricular remodelling. This document examines the proposed criteria to diagnose RR and AR, their prevalence and prognostic value, and the variables predicting remodelling in patients managed according to current guidelines. Much attention will be devoted to RR in patients with HFrEF because most studies on cardiac remodelling focused on this setting.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Jhund, Dr Pardeep
Authors: Aimo, A., Vergaro, G., González, A., Barison, A., Lupón, J., Delgado, V., Richards, A. M., de Boer, R. A., Thum, T., Arfsten, H., Hülsmann, M., Falcao‐Pires, I., Díez, J., Foo, R. S., Chan, M. Y. Y., Anene‐Nzelu, G. C., Abdelhamid, M., Adamopoulos, S., Anker, S. D., Belenkov, Y., Gal, T. B., Cohen‐Solal, A., Böhm, M., Chioncel, O., Jankowska, E. A., Gustafsson, F., Hill, L., Jaarsma, T., Januzzi, J. L., Jhund, P., Lopatin, Y., Lund, L. H., Metra, M., Milicic, D., Moura, B., Mueller, C., Mullens, W., Núñez, J., Piepoli, M. F., Rakisheva, A., Ristic, A., Rossignol, P., Savarese, G., Tocchetti, C. G., van Linthout, S., Volterrani, M., Seferovic, P., Rosano, G., Coats, A. J., Emdin, M., and Bayes‐Genis, A.
College/School:College of Medical Veterinary and Life Sciences > School of Cardiovascular & Metabolic Health
Journal Name:European Journal of Heart Failure
Publisher:Wiley
ISSN:1388-9842
ISSN (Online):1879-0844
Published Online:30 April 2022
Copyright Holders:Copyright © 2022 European Society of Cardiology
First Published:First published in European Journal of Heart Failure 24(6): 944-958
Publisher Policy:Reproduced in accordance with the publisher copyright policy

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