Law, S. M., Scott, K., Alkarn, A., Mahjoub, A., Mallik, A. K., Roditi, G. and Choo-Kang, B. (2022) COVID-19 associated phrenic nerve mononeuritis: a case series. Thorax, 77(8), pp. 834-838. (doi: 10.1136/thoraxjnl-2021-218257) (PMID:35459747)
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Abstract
This study characterised the hemidiaphragm elevation on 3-month interval chest X-rays (CXRs) of patients post COVID-19 pneumonia. 467 CXRs were screened; 19 (4.1%) had an elevated hemidiaphragm. There were 15 (3.2%) patients of interest with new hemidiaphragm elevation, persisting on average 7 months post COVID-19 diagnosis. Symptomatic patients underwent diaphragm ultrasound (n=12), pulmonary function test (n=10), muscle function test (n=6) and neurophysiology (n=5), investigating phrenic nerve function. Ultrasound demonstrated reduced/paradoxical diaphragmatic movements in eight; four of eight had reduced thickening fraction. Neurophysiology peripheral limb studies did not support the differential diagnoses of critical illness neuropathy/myopathy. We propose that, in selected patients, COVID-19 may cause phrenic nerve mononeuritis.
| Item Type: | Articles |
|---|---|
| Keywords: | Respiratory muscles, COVID-19, imaging/CT MRI. |
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Roditi, Dr Giles and Choo-Kang, Dr Brian and Mallik, Mr Arup |
| Authors: | Law, S. M., Scott, K., Alkarn, A., Mahjoub, A., Mallik, A. K., Roditi, G., and Choo-Kang, B. |
| College/School: | College of Medical Veterinary and Life Sciences > School of Cardiovascular & Metabolic Health College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing |
| Journal Name: | Thorax |
| Publisher: | BMJ Publishing Group |
| ISSN: | 0040-6376 |
| ISSN (Online): | 1468-3296 |
| Published Online: | 22 April 2022 |
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