Current insights into the bone marrow niche: from biology in vivo to bioengineering ex vivo

Xiao, Y., McGuinness, C. A.S., Doherty-Boyd, W. S., Salmeron-Sanchez, M. , Donnelly, H. and Dalby, M. J. (2022) Current insights into the bone marrow niche: from biology in vivo to bioengineering ex vivo. Biomaterials, 286, 121568. (doi: 10.1016/j.biomaterials.2022.121568)

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Abstract

Hematopoietic stem cells (HSCs) are fundamental to the generation of the body's blood and immune cells. They reside primarily within the bone marrow (BM) niche microenvironment, which provides signals responsible for the regulation of HSC activities. While our understanding of these signalling mechanisms continues to improve, our ability to recapitulate them in vitro to harness the clinical potential of the HSC populations is still lacking. Recent studies have applied novel engineering techniques combined with traditional in vitro work to establish ex vivo BM niche models. These models exhibit promising potential for research and clinical applications. In this review, BM niche factors that regulate the HSCs in vivo are discussed and their applications in the engineering of BM biomaterial-based platforms are considered. Many questions remain regarding the heterogeneity of niche components and the interactions of HSCs with their microenvironment. A greater understanding of the niche would help to elucidate these remaining questions, leading to the development of novel therapeutic tools.

Item Type:Articles
Additional Information:This review is funded by China Scholarship Council (#201908060063), Engineering and Physical Sciences Research Council (EP/P001114/1) and Biotechnology and Biological Sciences Research Council (BB/N018419/1).
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Salmeron-Sanchez, Professor Manuel and Dalby, Professor Matthew and McGuinness, Chanelle and Doherty-Boyd, Seb and Xiao, Yinbo and Donnelly, Miss Hannah
Authors: Xiao, Y., McGuinness, C. A.S., Doherty-Boyd, W. S., Salmeron-Sanchez, M., Donnelly, H., and Dalby, M. J.
College/School:College of Medical Veterinary and Life Sciences > Institute of Cancer Sciences
College of Medical Veterinary and Life Sciences > Institute of Molecular Cell and Systems Biology
College of Science and Engineering > School of Engineering > Biomedical Engineering
Journal Name:Biomaterials
Publisher:Elsevier
ISSN:0142-9612
ISSN (Online):1878-5905
Published Online:07 May 2022
Copyright Holders:Copyright © 2022 The Authors
First Published:First published in Biomaterials 286: 121568
Publisher Policy:Reproduced under a Creative Commons License

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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
173192Engineering growth factor microenvironments- a new therapeutic paradigm for regenerative medicineManuel Salmeron-SanchezEngineering and Physical Sciences Research Council (EPSRC)EP/P001114/1ENG - Biomedical Engineering
172752Materials exploitation of the biointerface to control MSC quality and niche phenotypeMatthew DalbyBiotechnology and Biological Sciences Research Council (BBSRC)BB/N018419/1Institute of Molecular, Cell & Systems Biology