Xiao, Y., McGuinness, C. A.S., Doherty-Boyd, W. S., Salmeron-Sanchez, M. , Donnelly, H. and Dalby, M. J. (2022) Current insights into the bone marrow niche: from biology in vivo to bioengineering ex vivo. Biomaterials, 286, 121568. (doi: 10.1016/j.biomaterials.2022.121568) (PMID:35580474)
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Abstract
Hematopoietic stem cells (HSCs) are fundamental to the generation of the body's blood and immune cells. They reside primarily within the bone marrow (BM) niche microenvironment, which provides signals responsible for the regulation of HSC activities. While our understanding of these signalling mechanisms continues to improve, our ability to recapitulate them in vitro to harness the clinical potential of the HSC populations is still lacking. Recent studies have applied novel engineering techniques combined with traditional in vitro work to establish ex vivo BM niche models. These models exhibit promising potential for research and clinical applications. In this review, BM niche factors that regulate the HSCs in vivo are discussed and their applications in the engineering of BM biomaterial-based platforms are considered. Many questions remain regarding the heterogeneity of niche components and the interactions of HSCs with their microenvironment. A greater understanding of the niche would help to elucidate these remaining questions, leading to the development of novel therapeutic tools.
| Item Type: | Articles |
|---|---|
| Additional Information: | This review is funded by China Scholarship Council (#201908060063), Engineering and Physical Sciences Research Council (EP/P001114/1) and Biotechnology and Biological Sciences Research Council (BB/N018419/1). |
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Salmeron-Sanchez, Professor Manuel and Dalby, Professor Matthew and McGuinness, Chanelle and Doherty-Boyd, Seb and Xiao, Yinbo and Donnelly, Dr Hannah |
| Authors: | Xiao, Y., McGuinness, C. A.S., Doherty-Boyd, W. S., Salmeron-Sanchez, M., Donnelly, H., and Dalby, M. J. |
| College/School: | College of Medical Veterinary and Life Sciences > School of Cancer Sciences College of Medical Veterinary and Life Sciences > School of Molecular Biosciences College of Science and Engineering > School of Engineering > Biomedical Engineering |
| Journal Name: | Biomaterials |
| Publisher: | Elsevier |
| ISSN: | 0142-9612 |
| ISSN (Online): | 1878-5905 |
| Published Online: | 07 May 2022 |
| Copyright Holders: | Copyright © 2022 The Authors |
| First Published: | First published in Biomaterials 286: 121568 |
| Publisher Policy: | Reproduced under a Creative Commons License |
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