A review of vascular traits and assessment techniques, and their heritability

Craig, A., Delles, C. and Murray, E. C. (2022) A review of vascular traits and assessment techniques, and their heritability. Artery Research, 28(2), pp. 61-78. (doi: 10.1007/s44200-022-00016-y)

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Abstract

Various tools are available to assess atherosclerosis, arterial stiffening, and endothelial function. They offer utility in the assessment of hypertensive phenotypes, in cardiovascular risk prediction, and as surrogate endpoints in clinical trials. We explore the relative influence of participant genetics, with reference to large-scale genomic studies, population-based cohorts, and candidate gene studies. We find heritability estimates highest for carotid intima-media thickness (CIMT 35–65%), followed by pulse wave velocity as a measure of arterial stiffness (26–43%), and flow mediated dilatation as a surrogate for endothelial function (14–39%); data were lacking for peripheral artery tonometry. We furthermore examine genes and polymorphisms relevant to each technique. We conclude that CIMT and pulse wave velocity dominate the existing evidence base, with fewer published genomic linkages for measures of endothelial function. We finally make recommendations regarding planning and reporting of data relating to vascular assessment techniques, particularly when genomic data are also available, to facilitate integration of these tools into cardiovascular disease research.

Item Type:Articles
Additional Information:Funding: E. Murray received European Research Council funding to undertake an MD as part of the Infammatension Study (Grant number ERC-2016-COG awarded to Prof T Guzik).
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Delles, Professor Christian and Murray, Dr Eleanor
Authors: Craig, A., Delles, C., and Murray, E. C.
College/School:College of Medical Veterinary and Life Sciences > School of Cardiovascular & Metabolic Health
Journal Name:Artery Research
Publisher:BioMed Central
ISSN:1872-9312
ISSN (Online):1876-4401
Published Online:01 June 2022
Copyright Holders:Copyright © 2022 The Authors
First Published:First published in Artery Research 28(2): 61-78
Publisher Policy:Reproduced under a Creative Commons License

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