Hofmann-Lehmann, R. et al. (2006) Reassessment of feline leukaemia virus (FeLV) vaccines with novel sensitive molecular assays. Vaccine, 24, pp. 1087-1094. (doi: 10.1016/j.vaccine.2005.09.010)
Full text not currently available from Enlighten.
Abstract
We previously described antigen negative, provirus positive cats. Subsequently, we hypothesized that efficacious FeLV vaccines cannot prevent minimal viral replication. Thus, we vaccinated cats with either a canarypox-vectored live or a killed virus vaccine and analyzed the challenge outcome with quantitative PCR and a newly established real-time RT-PCR. When judged by conventional parameters (antigenaemia, virus isolation), most of the vaccinated cats were, as expected, protected from persistent viraemia. However, all cats were found to be plasma viral RNA positive. The loads were significantly associated with the infection outcome. Thus, commonly used FeLV vaccines understood to be successful model antiretroviral vaccines protecting against FeLV-related diseases do not confer sterilizing immunity.
| Item Type: | Articles |
|---|---|
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | UNSPECIFIED |
| Authors: | Hofmann-Lehmann, R., Tandon, R., Boretti, F.S., Meli, M.L., Willi, B., Cattori, V., Gomes-Keller, M.A., Ossent, P., Golder, M.C., Flynn, J.N., and Lutz, H. |
| College/School: | College of Medical Veterinary and Life Sciences |
| Journal Name: | Vaccine |
| ISSN: | 0264-410X |
University Staff: Request a correction | Enlighten Editors: Update this record
Altmetric
Altmetric