Streng, K. W. et al. (2022) Clinical implications of low estimated protein intake in patients with heart failure. Journal of Cachexia, Sarcopenia and Muscle, 13(3), pp. 1762-1770. (doi: 10.1002/jcsm.12973) (PMID:35426256) (PMCID:PMC9178387)
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Abstract
Background: A higher protein intake has been associated with a higher muscle mass and lower mortality rates in the general population, but data about protein intake and survival in patients with heart failure (HF) are lacking. Methods: We studied the prevalence, predictors, and clinical outcome of estimated protein intake in 2516 patients from the BIOlogy Study to TAilored Treatment in Chronic Heart Failure (BIOSTAT-CHF) index cohort. Protein intake was calculated in spot urine samples using a validated formula [13.9 + 0.907 * body mass index (BMI) (kg/m2) + 0.0305 * urinary urea nitrogen level (mg/dL)]. Association with mortality was assessed using multivariable Cox regression models. All findings were validated in an independent cohort. Results: We included 2282 HF patients (mean age 68 ± 12 years and 27% female). Lower estimated protein intake in HF patients was associated with a lower BMI, but with more signs of congestion. Mortality rate in the lowest quartile was 32%, compared with 18% in the highest quartile (P < 0.001). In a multivariable model, lower estimated protein intake was associated with a higher risk of death compared with the highest quartile [hazard ratio (HR) 1.50; 95% confidence interval (CI) 1.03–2.18, P = 0.036 for the lowest quartile and HR 1.46; 95% CI 1.00–2.18, P = 0.049 for the second quartile]. Conclusions: An estimated lower protein intake was associated with a lower BMI, but signs of congestion were more prevalent. A lower estimated protein intake was independently associated with a higher mortality risk.
Item Type: | Articles |
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Additional Information: | This work was supported by the Netherlands Cardiovascular Research Initiative: an initiative with support of the Dutch Heart Foundation (CVON2014-11 RECONNECT) and a grant from the European Commission (FP7-242209-BIOSTAT-CHF). |
Status: | Published |
Refereed: | Yes |
Glasgow Author(s) Enlighten ID: | Cleland, Professor John |
Authors: | Streng, K. W., Hillege, H. L., Maaten, J. M., Veldhuisen, D. J., Dickstein, K., Ng, L. L., Samani, N. J., Metra, M., Ponikowski, P., Cleland, J. G., Anker, S. D., Romaine, S. P.R., Damman, K., Meer, P., Lang, C. C., and Voors, A. A. |
College/School: | College of Medical Veterinary and Life Sciences > School of Health & Wellbeing > Robertson Centre |
Journal Name: | Journal of Cachexia, Sarcopenia and Muscle |
Publisher: | Wiley |
ISSN: | 2190-5991 |
ISSN (Online): | 2190-6009 |
Published Online: | 14 April 2022 |
Copyright Holders: | Copyright © 2022 The Authors |
First Published: | First published in Journal of Cachexia, Sarcopenia and Muscle 13(3): 1762-1770 |
Publisher Policy: | Reproduced under a Creative Commons License |
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