Differences or disorders of sex development in boys: impact on fertility

Cavadias, I., Touraine, P. and Ahmed, S. F. (2022) Differences or disorders of sex development in boys: impact on fertility. Annales d'Endocrinologie, (doi: 10.1016/j.ando.2022.04.013) (PMID:35461886) (In Press)

[img] Text
269580.pdf - Accepted Version
Restricted to Repository staff only until 21 April 2023.
Available under License Creative Commons Attribution Non-commercial No Derivatives.

198kB

Abstract

Differences or disorders of sex development (DSD) include various congenital conditions in which chromosomal, gonadal, or anatomical sex development is atypical. The incidence varies according to the category of DSD but the total incidence is high if hypospadias and undescended testes are included. Fertility prospects may be a concern for DSD patients and their parents. With the development of modern medical technologies and treatment opportunities, fertility diagnostics, information, and treatment have changed. Assisted reproductive technology has developed during the past decades and has become more available with an improving success rate. Intracytoplasmic sperm injection and testicular sperm retrieval, have further improved the possibilities for men with DSD to become biological parents. Some studies have determined the presence of germ cells in the gonads of patients with DSD suggesting that the potential for fertility may be higher than previously thought. However, fertility outcomes among individuals with DSD have not been fully investigated. Moreover, previous study showed that information on fertility problems and treatment possibilities given to patients with DSD needs to be improved. The use of registries to study fertility outcomes is essential for a better knowledge of fertility in patients with these rare conditions.

Item Type:Articles
Status:In Press
Refereed:Yes
Glasgow Author(s) Enlighten ID:Ahmed, Professor Syed Faisal
Authors: Cavadias, I., Touraine, P., and Ahmed, S. F.
College/School:College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing
Journal Name:Annales d'Endocrinologie
Publisher:Elsevier
ISSN:0003-4266
ISSN (Online):2213-3941
Published Online:21 April 2022

University Staff: Request a correction | Enlighten Editors: Update this record