Clinical characteristics and survival in patients with heart failure experiencing in hospital cardiac arrest

Aune, E., McMurray, J. , Lundgren, P., Sattar, N. , Israelsson, J., Nordberg, P., Herlitz, J. and Rawshani, A. (2022) Clinical characteristics and survival in patients with heart failure experiencing in hospital cardiac arrest. Scientific Reports, 12, 5685. (doi: 10.1038/s41598-022-09510-4) (PMID:35383220) (PMCID:PMC8983650)

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Abstract

In patients with heart failure (HF) who suffered in-hospital cardiac arrest (IHCA), little is known about the characteristics, survival and neurological outcome. We used the Swedish Registry of Cardiopulmonary Resuscitation to study this, including patients aged ≥ 18 years suffering IHCA (2008-2019), categorised as HF alone, HF with acute myocardial infarction (AMI), AMI alone, or other. Odds ratios (OR) for 30-day survival, trends in 30-day survival, and the implication of HF phenotype was studied. 6378 patients had HF alone, 2111 had HF with AMI, 4210 had AMI alone. Crude 5-year survival was 9.6% for HF alone, 12.9% for HF with AMI and 34.6% for AMI alone. The 5-year survival was 7.9% for patients with HF and left ventricular ejection fraction (LVEF) ≥ 50%, 15.4% for LVEF < 40% and 12.3% for LVEF 40-49%. Compared with AMI alone, adjusted OR (95% CI) for 30-day survival was 0.66 (0.60-0.74) for HF alone, and 0.49 (0.43-0.57) for HF with AMI. OR for 30-day survival in 2017-2019 compared with 2008-2010 were 1.55 (1.24-1.93) for AMI alone, 1.37 (1.00-1.87) for HF with AMI and 1.30 (1.07-1.58) for HF alone. Survivors with HF had good neurological outcome in 92% of cases.

Item Type:Articles
Additional Information:Open access funding provided by University of Gothenburg. This work was supported by the Swedish Research Council [2019–02019] and the Swedish Heart and Lung Foundation [20200261].
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:McMurray, Professor John and Sattar, Professor Naveed
Authors: Aune, E., McMurray, J., Lundgren, P., Sattar, N., Israelsson, J., Nordberg, P., Herlitz, J., and Rawshani, A.
College/School:College of Medical Veterinary and Life Sciences > School of Cardiovascular & Metabolic Health
Journal Name:Scientific Reports
Publisher:Nature Research
ISSN:2045-2322
ISSN (Online):2045-2322
Copyright Holders:Copyright © 2022 The Authors
First Published:First published in Scientific Reports 12: 5685
Publisher Policy:Reproduced under a Creative Commons License

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