Development of a framework and decision tool for the evaluation of health technologies based on surrogate endpoint evidence

Ciani, O., Grigore, B. and Taylor, R. S. (2022) Development of a framework and decision tool for the evaluation of health technologies based on surrogate endpoint evidence. Health Economics, 31(S1), pp. 44-72. (doi: 10.1002/hec.4524) (PMID:35608044) (PMCID:PMC9546394)

Abstract

In the drive toward faster patient access to treatments, health technology assessment (HTA) agencies and payers are increasingly faced with reliance on evidence based on surrogate endpoints, increasing decision uncertainty. Despite the development of a small number of evaluation frameworks, there remains no consensus on the detailed methodology for handling surrogate endpoints in HTA practice. This research overviews the methods and findings of four empirical studies undertaken as part of COMED (Pushing the Boundaries of Cost and Outcome Analysis of Medical Technologies) program work package 2 with the aim of analyzing international HTA practice of the handling and considerations around the use of surrogate endpoint evidence. We have synthesized the findings of these empirical studies, in context of wider contemporary body of methodological and policy-related literature on surrogate endpoints, to develop a web-based decision tool to support HTA agencies and payers when faced with surrogate endpoint evidence. Our decision tool is intended for use by HTA agencies and their decision-making committees together with the wider community of HTA stakeholders (including clinicians, patient groups, and healthcare manufacturers). Having developed this tool, we will monitor its use and we welcome feedback on its utility.

• Item Type: Articles
• Additional Information: This project has received funding from the European Union's Horizon 2020 research and innovation program under Grant Agreement #779306.
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Ciani, Professor Oriana and Taylor, Professor Rod
• Authors: Ciani, O., Grigore, B., and Taylor, R. S.
• College/School: College of Medical Veterinary and Life Sciences > School of Health & Wellbeing > MRC/CSO SPHSU
• Journal Name: Health Economics
• Publisher: Wiley
• ISSN: 1057-9230
• ISSN (Online): 1099-1050
• Published Online: 24 May 2022
• Copyright Holders: Copyright © 2022 The Authors
• First Published: First published in Health Economics 31(S1): 44-72
• Publisher Policy: Reproduced under a Creative Commons license