Nuclear interactions: a spotlight on nuclear mitochondrial membrane contact sites

Ovciarikova, J., Shikha, S. and Sheiner, L. (2022) Nuclear interactions: a spotlight on nuclear mitochondrial membrane contact sites. Contact, 5, p. 25152564221096217. (doi: 10.1177/25152564221096217) (PMID:36338149) (PMCID:PMC9623421)

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Abstract

Membrane contact sites (MCS) are critical for cellular functions of eukaryotes, as they enable communication and exchange between organelles. Research over the last decade unravelled the function and composition of MCS between a variety of organelles including mitochondria, ER, plasma membrane, lysosomes, lipid droplets, peroxisome and endosome, to name a few. In fact, MCS are found between any pair of organelles studied to date, with common functions including lipid exchange, calcium signalling and organelle positioning in the cell. Work in the past year has started addressing the composition and function of nuclear-mitochondrial MCS. Tether components mediating these contacts in yeast have been identified via comprehensive phenotypic screens, which also revealed a possible link between this contact and phosphatidylcholine metabolism. In human cells, and in the protozoan parasites causing malaria, proximity between these organelles is proposed to promote cell survival via a mitochondrial retrograde response. These pioneering studies should inspire the field to explore what cellular processes depend on the exchange between the nucleus and the mitochondrion, given that they play such central roles in cell biology.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Ovciarikova, Miss Jana and Sheiner, Professor Lilach
Authors: Ovciarikova, J., Shikha, S., and Sheiner, L.
College/School:College of Medical Veterinary and Life Sciences > School of Infection & Immunity
Journal Name:Contact
Publisher:SAGE Publications
ISSN:2515-2564
ISSN (Online):2515-2564
Copyright Holders:Copyright © 2022 The Authors
First Published:First published in Contact 5: 25152564221096217
Publisher Policy:Reproduced under a Creative Commons License

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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
172187Dissection of the unusual mitochondrial tRNA import translocon of Toxoplasma gondiiLilach SheinerBiotechnology and Biological Sciences Research Council (BBSRC)BB/N003675/1Institute of Infection, Immunity & Inflammation
307056Lost in translation. A study of the divergent mitochondrial translation pathway of the parasite Toxoplasma gondiiLilach SheinerWellcome Trust (WELLCOTR)217173/Z/19/ZMVLS - Polyomics Facility