Goodfellow, I.G., Sioofy, A.B., Powell, R.M. and Evans, D.J. (2001) Echoviruses bind heparan sulfate at the cell surface. Journal of Virology, 75, pp. 4918-4921.
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Abstract
Some echoviruses (EV) that bind decay-accelerating factor (DAF) also bind cells of human and murine origins in a DAF-independent manner. Pretreatment of cells with heparinase 1 or heparin blocks the binding of radiolabeled virus to the cell surface, and heparin prevents infection of rhabdomyosarcoma cells by certain EV, including several low-passage clinical isolates of EV 6 and some EV that do not bind DAF. These studies suggest that heparan sulfate may be of in vivo relevance as an attachment molecule for EV.
| Item Type: | Articles |
|---|---|
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | UNSPECIFIED |
| Authors: | Goodfellow, I.G., Sioofy, A.B., Powell, R.M., and Evans, D.J. |
| College/School: | College of Medical Veterinary and Life Sciences |
| Journal Name: | Journal of Virology |
| Journal Abbr.: | J. Virol. |
| ISSN: | 0022-538X |
| ISSN (Online): | 1098-5514 |
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