Schijns, V.E.J.C., Scholtes, N.C., van Zuilekom, H.I., Sanders, L.E.H.H., Nicolson, L. and Argyle, D.J. (2002) Facilitation of antibody forming responses to viral vaccine antigens in young cats by recombinant baculovirus-expressed feline IFN. Vaccine, 20(13-14), pp. 1718-1724. (doi: 10.1016/S0264-410X(02)00044-0)
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Abstract
We assessed the effect of recombinant feline IFN-γ as vaccine adjuvant for in vivo antibody responses of young 3-month-old kittens to inactivated antigens of rabies and calicivirus, both natural pathogens for cats. When compared to responses following immunization with antigen alone co-administration of baculovirus-expressed cat IFN-γ significantly enhanced serum antibody titers to both viral antigens; to levels comparable with responses evoked by commonly known saponin and alum adjuvants. Adjuvanticity by feline IFN-γ was dose-dependent and all doses tested were well tolerated. We conclude that, when further optimized for in vivo delivery, feline IFN-γ may represent a safe and efficient natural vaccine adjuvant for certain antigens in cats.
| Item Type: | Articles |
|---|---|
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Nicolson, Dr Lesley |
| Authors: | Schijns, V.E.J.C., Scholtes, N.C., van Zuilekom, H.I., Sanders, L.E.H.H., Nicolson, L., and Argyle, D.J. |
| College/School: | College of Medical Veterinary and Life Sciences > School of Biodiversity, One Health & Veterinary Medicine |
| Journal Name: | Vaccine |
| ISSN: | 0264-410X |
| ISSN (Online): | 1873-2518 |
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