Maintaining success for patients with dilated cardiomyopathy and remission of heart failure

Halliday, B. P. and Cleland, J. G. F. (2022) Maintaining success for patients with dilated cardiomyopathy and remission of heart failure. JACC: Basic to Translational Science, 7(5), pp. 500-503. (doi: 10.1016/j.jacbts.2022.03.008)

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Abstract

Remission of heart failure, defined by resolution of symptoms, normalization of left ventricular ejection fraction, and plasma concentrations of natriuretic peptides and by the ability to withdraw diuretic agents without recurrence of congestion is increasingly recognized among patients with dilated cardiomyopathy. Once remission has been achieved, it is unclear which treatments need to be continued long term. The durability of remission and likelihood of relapse are likely to be determined by intrinsic myocardial susceptibility, the persistence or recurrence of any acquired triggers, and current and future myocardial workload. Each of these should be addressed to enable personalized therapy to delay or prevent relapse. Management should be informed by evidence from randomized trials of targeted therapeutic strategies.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Cleland, Professor John
Authors: Halliday, B. P., and Cleland, J. G. F.
College/School:College of Medical Veterinary and Life Sciences > Institute of Health and Wellbeing > Robertson Centre
Journal Name:JACC: Basic to Translational Science
Publisher:Elsevier
ISSN:2452-302X
ISSN (Online):2452-302X
Published Online:23 May 2022
Copyright Holders:Copyright © 2022 The Authors
First Published:First published in JACC: Basic to Translational Science 7(5): 500-503
Publisher Policy:Reproduced under a Creative Commons License

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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
303944BHF Centre of ExcellenceColin BerryBritish Heart Foundation (BHF)RE/18/6/34217CAMS - Cardiovascular Science