Govender, K., Parboosing, R., Camiolo, S. , Suarez, N. M., Hubacek, P., Görzer, I. and Puchhammer-Stöckl, E. (2022) Complexity of human cytomegalovirus infection in South African HIV-exposed infants with pneumonia. Viruses, 14(5), 855. (doi: 10.3390/v14050855) (PMID:35632596) (PMCID:PMC9147013)
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Abstract
Human cytomegalovirus (HCMV) can cause significant end-organ diseases such as pneumonia in HIV-exposed infants. Complex viral factors may influence pathogenesis including: a large genome with a sizeable coding capacity, numerous gene regions of hypervariability, multiple-strain infections, and tissue compartmentalization of strains. We used a whole genome sequencing approach to assess the complexity of infection by comparing high-throughput sequencing data obtained from respiratory and blood specimens of HIV-exposed infants with severe HCMV pneumonia with those of lung transplant recipients and patients with hematological disorders. There were significantly more specimens from HIV-exposed infants showing multiple HCMV strain infection. Some genotypes, such as UL73 G4B and UL74 G4, were significantly more prevalent in HIV-exposed infants with severe HCMV pneumonia. Some genotypes were predominant in the respiratory specimens of several patients. However, the predominance was not statistically significant, precluding firm conclusions on anatomical compartmentalization in the lung.
| Item Type: | Articles |
|---|---|
| Additional Information: | Funding: This research was funded by the Carnegie Trust for the Universities of Scotland (grant RIG007549 to N.M.S.); National Health Laboratory Service Research Trust Grant (grant 94612 to K.G.); the South Africa National Research Foundation Thuthuka Funding Instrument (grant 113351 to K.G.); the CAPRISA Self-funded Fellowship (grant 55878 to K.G.); the Ministry of Health of the Czech Republic (grant 0064203 to P.H.); and the Medical Research Council, United Kingdom (grant number MC_UU_12014/3 to N.M.S.). |
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Suarez, Dr Nicolas and Camiolo, Dr Salvatore |
| Authors: | Govender, K., Parboosing, R., Camiolo, S., Suarez, N. M., Hubacek, P., Görzer, I., and Puchhammer-Stöckl, E. |
| College/School: | College of Medical Veterinary and Life Sciences > School of Infection & Immunity > Centre for Virus Research |
| Journal Name: | Viruses |
| Publisher: | MDPI |
| ISSN: | 1999-4915 |
| ISSN (Online): | 1999-4915 |
| Published Online: | 21 April 2022 |
| Copyright Holders: | Copyright © 2022 by the authors |
| First Published: | First published in Viruses |
| Publisher Policy: | Reproduced under a Creative Commons license |
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