Cu2O-based electrochemical biosensor for non-invasive and portable glucose detection

Fantinelli Franco, F., Hogg, R. A. and Manjakkal, L. (2022) Cu2O-based electrochemical biosensor for non-invasive and portable glucose detection. Biosensors, 12(3), 174. (doi: 10.3390/bios12030174)

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Abstract

Electrochemical voltammetric sensors are some of the most promising types of sensors for monitoring various physiological analytes due to their implementation as non-invasive and portable devices. Advantages in reduced analysis time, cost-effectiveness, selective sensing, and simple techniques with low-powered circuits distinguish voltammetric sensors from other methods. In this work, we developed a Cu2O-based non-enzymatic portable glucose sensor on a graphene paste printed on cellulose cloth. The electron transfer of Cu2O in a NaOH alkaline medium and sweat equivalent solution at very low potential (+0.35 V) enable its implementation as a low-powered portable glucose sensor. The redox mechanism of the electrodes with the analyte solution was confirmed through cyclic voltammetry, differential pulse voltammetry, and electrochemical impedance spectroscopy studies. The developed biocompatible, disposable, and reproducible sensors showed sensing performance in the range of 0.1 to 1 mM glucose, with a sensitivity of 1082.5 ± 4.7% µA mM−1 cm−2 on Cu2O coated glassy carbon electrode and 182.9 ± 8.83% µA mM−1 cm−2 on Cu2O coated graphene printed electrodes, making them a strong candidate for future portable, non-invasive glucose monitoring devices on biodegradable substrates. For portable applications we demonstrated the sensor on artificial sweat in 0.1 M NaOH solution, indicating the Cu2O nanocluster is selective to glucose from 0.0 to +0.6 V even in the presence of common interference such as urea and NaCl.

Item Type:Articles
Additional Information:This work was supported by the European Commission through the AQUASENSE (H2020- MSCA-ITN-2018-813680) project and NERC discipline hopping activities to tackle environmental challenges project (SEED-2022-317475).
Keywords:Glucose sensor, Cu2O nanomaterial, electrochemical sensor, non-enzymatic sensor.
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Fantinelli Franco, Ms Fabiane and Hogg, Professor Richard and Manjakkal, Dr Libu
Authors: Fantinelli Franco, F., Hogg, R. A., and Manjakkal, L.
College/School:College of Science and Engineering > School of Engineering > Electronics and Nanoscale Engineering
College of Science and Engineering > School of Engineering > Infrastructure and Environment
Journal Name:Biosensors
Publisher:MDPI
ISSN:2079-6374
ISSN (Online):2079-6374
Published Online:14 March 2022
Copyright Holders:Copyright © 2022 The Authors
First Published:First published in Biosensors 12(3): 174
Publisher Policy:Reproduced under a Creative Commons License

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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
303114Innovative Network for Training in Water and Food Quality using Disposable Sensors,Ravinder DahiyaEuropean Commission (EC)813680ENG - Electronics & Nanoscale Engineering