Cu2O-based electrochemical biosensor for non-invasive and portable glucose detection

Fantinelli Franco, F. , Hogg, R. A. and Manjakkal, L. (2022) Cu2O-based electrochemical biosensor for non-invasive and portable glucose detection. Biosensors, 12(3), 174. (doi: 10.3390/bios12030174)

Abstract

Electrochemical voltammetric sensors are some of the most promising types of sensors for monitoring various physiological analytes due to their implementation as non-invasive and portable devices. Advantages in reduced analysis time, cost-effectiveness, selective sensing, and simple techniques with low-powered circuits distinguish voltammetric sensors from other methods. In this work, we developed a Cu2O-based non-enzymatic portable glucose sensor on a graphene paste printed on cellulose cloth. The electron transfer of Cu2O in a NaOH alkaline medium and sweat equivalent solution at very low potential (+0.35 V) enable its implementation as a low-powered portable glucose sensor. The redox mechanism of the electrodes with the analyte solution was confirmed through cyclic voltammetry, differential pulse voltammetry, and electrochemical impedance spectroscopy studies. The developed biocompatible, disposable, and reproducible sensors showed sensing performance in the range of 0.1 to 1 mM glucose, with a sensitivity of 1082.5 ± 4.7% µA mM−1 cm−2 on Cu2O coated glassy carbon electrode and 182.9 ± 8.83% µA mM−1 cm−2 on Cu2O coated graphene printed electrodes, making them a strong candidate for future portable, non-invasive glucose monitoring devices on biodegradable substrates. For portable applications we demonstrated the sensor on artificial sweat in 0.1 M NaOH solution, indicating the Cu2O nanocluster is selective to glucose from 0.0 to +0.6 V even in the presence of common interference such as urea and NaCl.

• Item Type: Articles
• Additional Information: This work was supported by the European Commission through the AQUASENSE (H2020- MSCA-ITN-2018-813680) project and NERC discipline hopping activities to tackle environmental challenges project (SEED-2022-317475).
• Keywords: Glucose sensor, Cu2O nanomaterial, electrochemical sensor, non-enzymatic sensor.
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Fantinelli Franco, Ms Fabiane and Hogg, Professor Richard and Manjakkal, Dr Libu
• Authors: Fantinelli Franco, F., Hogg, R. A., and Manjakkal, L.
• College/School: College of Science and Engineering > School of Engineering > Electronics and Nanoscale Engineering; College of Science and Engineering > School of Engineering > Infrastructure and Environment
• Journal Name: Biosensors
• Publisher: MDPI
• ISSN: 2079-6374
• ISSN (Online): 2079-6374
• Published Online: 14 March 2022
• Copyright Holders: Copyright © 2022 The Authors
• First Published: First published in Biosensors 12(3): 174
• Publisher Policy: Reproduced under a Creative Commons License

Project Code	Award No	Project Name	Principal Investigator	Funder's Name	Funder Ref	Lead Dept
303114		Innovative Network for Training in Water and Food Quality using Disposable Sensors,	Ravinder Dahiya	European Commission (EC)	813680	ENG - Electronics & Nanoscale Engineering