Raman spectroscopy in prostate cancer: techniques, applications and advancements

Gaba, F., Tipping, W. J., Salji, M. , Faulds, K., Graham, D. and Leung, H. Y. (2022) Raman spectroscopy in prostate cancer: techniques, applications and advancements. Cancers, 14(6), 1535. (doi: 10.3390/cancers14061535)

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Abstract

Optical techniques are widely used tools in the visualisation of biological species within complex matrices, including biopsies, tissue resections and biofluids. Raman spectroscopy is an emerging analytical approach that probes the molecular signature of endogenous cellular biomolecules under biocompatible conditions with high spatial resolution. Applications of Raman spectroscopy in prostate cancer include biopsy analysis, assessment of surgical margins and monitoring of treatment efficacy. The advent of advanced Raman imaging techniques, such as stimulated Raman scattering, is creating opportunities for real-time in situ evaluation of prostate cancer. This review provides a focus on the recent preclinical and clinical achievements in implementing Raman-based techniques, highlighting remaining challenges for clinical applications. The research and clinical results achieved through in vivo and ex vivo Raman spectroscopy illustrate areas where these evolving technologies can be best translated into clinical practice.

Item Type:Articles
Additional Information:This work was supported by the Medical Research Council Clinical Research Training Fellow-ship awarded to MS (MR/L017997/1) and CRUK Beatson Institute core funding (C596/A31287) and CRUK core group awarded to HYL (A15151).
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Salji, Dr Mark and Gaba, Dr Fortis and Leung, Professor Hing and Graham, Professor Duncan
Creator Roles:
Gaba, F.Investigation, Writing – original draft
Salji, M.Conceptualization, Investigation
Graham, D.Writing – review and editing
Leung, H. Y.Conceptualization, Writing – review and editing
Authors: Gaba, F., Tipping, W. J., Salji, M., Faulds, K., Graham, D., and Leung, H. Y.
College/School:College of Medical Veterinary and Life Sciences > Institute of Cancer Sciences
College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing
College of Science and Engineering > School of Chemistry
Journal Name:Cancers
Publisher:MDPI
ISSN:2072-6694
ISSN (Online):2072-6694
Copyright Holders:Copyright © 2022 by the Authors
First Published:First published in Cancers 14(6):1535
Publisher Policy:Reproduced under a Creative Commons licence

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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
170128Quantitative proteomic analysis of castrate-resistant prostate cancerHing LeungMedical Research Council (MRC)MR/L017997/1Institute of Cancer Sciences